张振宾

发布时间:2020-06-22  作者:  点击量:




张振宾 博士

研究员

Email:zhangzhenbin@nbu.edu.cn

研究领域:

整体材料制备方法及应用

毛细管电泳与质谱联用技术及应用

高通量高灵敏度蛋白质组学研究集成平台

多组学整合分析技术

临床蛋白质组学(药物靶点、疾病标志物及肿瘤微环境)

单细胞蛋白质组学


 个人简介:

张振宾博士,宁波大学新药技术研究院研究员,硕士生导师。 2013年在中国科学院大连化学物理研究所获得分析化学博士学位。同年加入美国圣母大学(University of Notre Dame)化学与生物化学系进行博士后研究,师从Norman J Dovichi教授。2016年被美国圣母大学聘为研究助理教授,作为核心骨干参与了美国国立卫生研究院(NIH)项目3项,曾荣获由北美华人色谱协会(CACA)颁发的2021青年科学家奖(2021 Young Investigator Award)。2021年起受聘宁波大学新药技术研究院研究员。在分离材料的制备、蛋白质组学微量样品预处理、毛细管液相色谱-质谱联用、毛细管电泳与质谱联用、高通量高灵敏蛋白质组学分析等领域取得了一系列开创性研究成果,为推动该领域的发展做出了突出贡献,得到国际同行高度关注和认可。近年来,在包括Trends in Analytical Chemistry、Analytical chemistry等国际知名学术期刊上发表学术论文 40余篇(第一作者论文 19 篇),引用1700余次,h指数22(Google Scholar)。已申请4项专利(2项中国专利,2项美国专利)。多次参加HPLC、ASMS、PITTCON等重要国际学术会议并做学术报告。受邀在 Springer撰写第一作者专著 1 章。受邀担任Frontiers in Chemistry、Molecules杂志客座主编以及 Analytical Chemistry等十余个国际著名期刊独立审稿人。受邀担任印第安那临床转化医学中心(Indiana CTSI) Core Pilot Founding Program基金评审专家。


教育与科研经历:

2002.09-2006.06

中南大学,无机非金属材料工程,学士

2006.09-2009.06

华南师范大学,应用化学,硕士研究生

2009.09-2013.07

中科院大连化物所,分析化学,博士研究生

2013.10-2016.09

University of Notre Dame,博士后

2016.10-2021.01

University of Notre Dame,研究助理教授

2021.04-至今

宁波大学新药技术研究院,研究员


奖项荣誉:

2021 Chinese American Chromatography Association Young Investigator Award

2019 175th SUSTech Chemical Sciences Lectureship

2018 Finalists for Consideration of the 2018 Csaba Horváth Young Scientist Award at HPLC 2018  

2013 中科院大连化物所-延长石油奖学金一等奖


2012 中科院大连化物所DICP-Corning奖学金

2012  The poster was nominated amongst the 30 best poster presented at HPLC 2012


国际学术会议:

1. 2nd Annual North American Mass Spectrometry Summer School, Madison, Wisconsin, USA, July 21-24, 2019. (Poster)

2. 67th ASMS Conference on Mass Spectrometry and Allied Topics, Atlanta, Georgia, June 2-6, 2019. (Oral presentation)

3. Pittcon Conference & Expo 2019, Philadelphia, PA. March 17-21, 2019. (Oral presentation)

4. 47th International Symposium on High Performance Liquid Phase Separation and Related Techniques (HPLC2018), Marriott Wardman Park, Washington DC, USA, July 29-August 2, 2018. (Oral presentation)

5. Pittcon Conference & Expo 2018, Orlando, FL, USA, Feb 26-Mar 1, 2018. (Oral presentation)

6. 65th ASMS Conference on Mass Spectrometry and Allied Topics, Indianapolis, IN, June 4-8, 2017. (Poster)

7. 44th International Symposium on High Performance Liquid Phase Separation and Related Techniques (HPLC 2016). San Francisco, CA, June 19-24, 2016. (Oral presentation)

8. 63rd ASMS Conference on Mass Spectrometry and Allied Topics. St. Louis, Missouri, May 31-June 4, 2015. (Poster)

9. 第19届全国色谱学术报告及仪器展览会,福州,福建,4月 1-3日, 2013. (Oral presentation)

10. 38th International Symposium on High Performance Liquid Phase Separations and Related Techniques (HPLC 2012). Anaheim, CA, June 16-21, 2012. (Poster)

11. The 11th Asian Conference On Analytical Sciences (Asianal Ysis Xi). Jinling Conference Center, Nanjing, China, August 23-26, 2011. (Poster)


代表性论文:

[1] Zhang, Z. B., Dubiak, K. M., Huber, P. W., Dovichi, N. J. Miniaturized Filter-Aided Sample Preparation (MICRO-FASP) Method for High Throughput, Ultrasensitive Proteomics Sample Preparation Reveals Proteome Asymmetry in Xenopus laevis Embryos. Anal. Chem. 2020, 92 (7), 5554-5560.

[2] Zhang, Z. B., Hebert, A. S., Westphall, M. S., Coon, J. J., Dovichi, N. J. Single-Shot Capillary Zone Electrophoresis-Tandem Mass Spectrometry Produces over 4400 Phosphopeptide Identifications from a 220 ng Sample. J. Proteome Res. 2019, 18, 8, 3166-3173.

[3] Zhang, Z. B., Qu, Y. Y., Dovichi, N. J. Capillary zone electrophoresis-mass spectrometry for bottom-up proteomics. Trends Anal. Chem. 2018, 108, 23-37.

[4] Zhang, Z. B., Hebert, A. S., Westphall, M., Qu, Y. Y., Coon, J. J., Dovichi, N. J. Production of Over 27 000 Peptide and Nearly 4400 Protein Identifications by Single-Shot Capillary-Zone Electrophoresis–Mass Spectrometry via Combination of a Very-Low-Electroosmosis Coated Capillary, a Third-Generation Electrokinetically-Pumped Sheath-Flow Nanospray Interface, an Orbitrap Fusion Lumos Tribrid Mass Spectrometer, and an Advanced-Peak-Determination Algorithm. Anal. Chem. 2018, 90 (20), 12090-12093.

[5] Zhang, Z. B., Dovichi, N. J. Optimization of mass spectrometric parameters improve the identification performance of capillary zone electrophoresis for single-shot bottom-up proteomics analysis. Anal. Chim. Acta 2018, 1001, 93-99.

[6] Zhang, Z. B., Peuchen, E. H., Dovichi, N. J. Surface-Confined Aqueous Reversible Addition–Fragmentation Chain Transfer (SCARAFT) Polymerization Method for Preparation of Coated Capillary Leads to over 10 000 Peptides Identified from 25 ng HeLa Digest by Using Capillary Zone Electrophoresis-Tandem Mass Spectrometry. Anal. Chem. 2017, 89, 6774-6780.

[7] Zhang, Z. B., Zhu, G., Peuchen, E. H., Dovichi, N. J. Preparation of linear polyacrylamide coating and strong cationic exchange hybrid monolith in a single capillary, and its application as an automated platform for bottom-up proteomics by capillary electrophoresis-mass spectrometry. Microchim. Acta 2017, 184, 921-925.

[8] Zhang, Z. B., Albanetti, T., Linkous, T., Larkin, C. J., Schoner, R., McGivney, J. B., Dovichi, N. J. Comprehensive analysis of host cell impurities in monoclonal antibodies with improved sensitivity by capillary zone electrophoresis mass spectrometry. Electrophoresis 2017, 38, 401-407.

[9] Zhang, Z. B., Sun, L. L, Zhu, G. J., Cox, O. F., Huber, P. W., Dovichi, N. J. Nearly 1000 Protein Identifications from 50 ng of Xenopus laevis Zygote Homogenate Using Online Sample Preparation on a Strong Cation Exchange Monolith Based Microreactor Coupled with Capillary Zone Electrophoresis. Anal. Chem. 2016, 88, 877-882.

[10] Zhang, Z. B., Yan, X. J., Sun, L. L., Zhu, G. J., Dovichi, N. J. Detachable strong cation exchange monolith, integrated with capillary zone electrophoresis and coupled with ph gradient elution, produces improved sensitivity and numbers of peptide identifications during bottom-up analysis of complex proteomes. Anal. Chem. 2015, 87, 4572-4577.

[11] Zhang, Z. B., Sun, L. L., Zhu, G. J., Yan, X. J., Dovichi, N. J. Integrated strong cation-exchange hybrid monolith coupled with capillary zone electrophoresis and simultaneous dynamic pH junction for large-volume proteomic analysis by mass spectrometry. Talanta 2015, 138, 117-122.

 

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