研究队伍

教授

Email：liuxinmin(AT)nbu.edu.cn

学科方向：

中药、航天医学、动物模型

个人简介：

刘新民，医学博士。现为宁波大学新药技术研究院首席科学家、二级教授、博士生导师；世界卫生组织传统医学顾问；中国营养学会食药同源产业发展分会主任委员；中国实验动物学会动物模型鉴定与评价委员会主任委员、全国实验动物标准化委员会技术专家组组长；国家中医药管理局中国-巴基斯坦中医药合作中心主任；国家食药同源产业科技创新联盟副理事长；国家载人航天工程医学专家组成员；浙江-巴基斯坦传统药物研发联合实验室主任；COMSTECH传统医学专家委员会主席。从事基于动物行为实验的神经精神药理实验方法和中药新药研发、航天特因环境应激损伤中药防护、药食同源产品功效评价近四十年。

参加工作以来，先后获得国家自然科学基金、新药创制重大专项、国际合作重点课题和重点研发计划等30多项国家和省部课题。先后获得国家发明专利10余项，国家和部委奖励10多项，2022年获得阿联酋总统国际传统医学和补充替代医学奖。以第一或通讯作者发表学术论文200余篇，包括SCI论文100余篇。培养毕业硕士和博士研究生50多名。

教育与研究工作经历：

2022.8-迄今  

宁波大学新药技术研究院，教授/首席科学家。

2003.2-2022.8

中国医学科学院药用植物研究所，先后任天然药物研究中心副主任、药理毒理研究中心主任；二级教授、博士生导师（期间2015年、2018-2019年作为传统医学顾问在瑞士日内瓦世界卫生组织总部工作）。

1998-2003

阿联酋卫生部聘为传统医学专家，在阿联酋国家草药研究中心工作。

1984-1998

在中国医学科学院（北京协和医学院）药用植物研究所工作（其间1988-1991攻读硕士学位；1993-1996攻读博士学位）。1994、1997年在中国医学科学院（北京协和医学院）破格提拔为副教授、教授。

1984

毕业于湘雅（湖南）医学院，获得医学学士学位；1991年、1996年先后毕业于北京协和医学院（原中国协和医科大学），分别获得医学硕士、医学博士学位。

完成的主要工作和取得的主要成绩：

1. 与中国航天员中心陈善广将军团队合作二十多年，自主研发功能完整、体系完善，具自主知识产权的高自动化和智能化的中药神经精神行为药效评价仪器装置；创立了以航天等特因环境损伤为特点的学习记忆、情绪、体力疲劳等功能性损伤动物模型和药（功）效评价技术体系，形成了基于动物行为药理，灵敏快速、客观规范的学习记忆、抗抑郁、抗焦虑、改善睡眠和缓解体力疲劳等神经精神中药药效和功能食品评价技术体系。先后被中国医学科学院实验动物研究所/神经科学研究中心、军事医学科学院、国防科学技术大学、中国中医科学院、北京中医药大学、湖南中医药大学和中国农业科学院等单位采用进行中药药效和功能食品研究。目前作为我国人因重点实验室、航天医学基础与应用航天医学领域两大国家重点实验室用于航天特因环境脑功能研究和脑健康产品研发的核心支撑技术。

2. 完成了开心散、参远苷、人参、远志、天麻、荷叶、石斛、黄精、红枣等30多种中药、200个有效组份和40多个单体改善学习记忆、抗抑郁、抗疲劳药效物质基础和作用机制研究。获得了多个有良好成药性前景的中药候选新药，其中6个获得加拿大卫生部天然健康产品证书。相关研究成果在Science专刊上发表；先后多次获得国家中医药国际合作、国家重大新药创制专项资助。

3. 发现来源于人参和西洋参的达玛烷苷元及代谢产物对航天特因环境所致的学习记忆功能减退、抑郁症状有明显的改善作用，为国内外最早开始航天中药研究的团队。牵头组织浙贝母、黄精、黄花菜等多个食药同源品种，以及7种巴基斯坦药材的航天搭载和品质评价研究。负责空间站中药预研课题-微重力环境下中药防护神经干细胞作用研究。形成了在国内外具重要影响、独具特色的航天中药研究方向。

4. 与加拿大、美国，以及巴基斯坦、葡萄牙、英国、意大利、卢森堡等“一带一路“国家著名高校在研究生培养、产品研发和注册方面建立了长期稳定的科技合作关系。牵头在国外建立了中国-卢森堡、中国-葡萄牙、中国-巴基斯坦等多个国家级中医药国际合作中心。

 目前开展的工作：

聚焦航天应激损伤防护，在构建航天药效和功效评价技术体系的基础上，以中药、海洋药物为对象，研发新型安全有效的中药药物和健康产品；依托我国空间站这一国际特有的宝贵资源，开展航天中药育种和品质评价研究，以及空间站中药神经功能保护在轨研究，推动建立我国原创的太空中药制药新技术；加强基于空间站的“一带一路”中（草）药国际合作，打造国内外独具特色和影响力、面向空间站应用的中药研发平台和国际合作中心。

课题组研究方向包括：

1. 基于动物行为实验的神经精神药理实验方法研究。

2. 脑健康天然药物药（功）效评价及作用机制研究。

3. 航天中药育种和品质评价研究。

4. 防护神经精神疾病和功能性紊乱的中药新药、功能食品的物质基础、质量控制及制剂研究。

承担和完成的课题（近5年）：

1、国家中医药管理局中医药国际合作专项（GZYYGJ2020023），中国-巴基斯坦中医药中心，2020.10-2024.12，负责。

2、国家重点研发计划（科技（023YFF0724802），药物评价用人类重大疾病动物模型创制与应用研究-重大脑病动物模型的建立及药效评价，2024.01-2028.12，负责。

3、国家载人航天工程专项，航天特因环境神经功能紊乱中药防护关键技术研究，2024.01-2026.12，负责。

4、“一带一路”创新人才交流外国专家项目（DL2023018005L），中巴传统药物航天育种和品质评价国际合作研究，2023.08-2024.08，负责。

5、新疆科技厅项目，红枣加工品质提升技术集成与功能性产品开发-红枣抗抑郁成药性研究，2024.01-2028.12，负责。

6、国家载人航天工程预研项目，基于神经-内分泌-免疫调节的开心散化裁方防护失重效应诱发的认知功能减退研究，2019.10-2024.10，负责。

7、宁波市重点专项，基于太空搭载的浙贝母育种与品质评价研究，2023.01-2025.12，主要承担人。

获得的成果奖励和专利：

1、阿联酋Zayed总统传统医学和替代医学奖，阿联酋Zayed总统基金会，国际传统医药奖，2022。刘新民。

2、航天特因环境神经功能损伤防护技术研究，军队科学技术进步奖，二等，2020。曲丽娜、李莹辉、陈海龙、刘新民、费俊龙、冀国华、吕柯、王琼、梁峰吉、常琪。

3、体现中药特点的新药评价标准研究，中华中医药学会，二等，2008。王北婴、刘新民、叶祖光、念娥美、胡镜清、陈士林、杜晓曦、林瑞超、乔延江、王琼、刘陆阳、刘保延、许青峰、钱忠直。

4、泽兰抗模拟失重时血液流变学异常改变的效应机制，中国人民解放军总后勤部，三等，2006。李勇枝、高南南、刘新民、范全春、高建义等。

5、中药现代化发展战略研究，国家，二等，1999。甘师俊、李振吉、邹建强、许有玲、 贾谦、洪 净、王北婴、崔蒙、陈峰、刘新民。

6、动物学习记忆计算机测控系统的研制和实验方法的研究，国防科工委，二等。1998，陈善广、刘新民、邢志新、王立为、孟慧、王圣平。

7、中药现代化发展战略研究，科技部，二等，1998。甘师俊、李振吉、邹建强、许有玲、 贾谦、洪 净、王北婴、崔蒙、陈峰、刘新民。

以通讯作者发表的主要文章（近5年）：

1. Chen F, Jiang N, Zhang YW, Xie MZ, Liu XM. Protective effect of Gastrodia elata blume ameliorates simulated weightlessness-induced cognitive impairment in mice. Life Sci Space Res (Amst). 2023 Feb;36:1-7. (IF=2.5)

2. Yao C, Zhang Y, Sun X, Pei H, Wei S, Wang M, Chang Q, Liu X, Jiang N. Areca catechu L. ameliorates chronic unpredictable mild stress-induced depression behavior in rats by the promotion of the BDNF signaling pathway. Biomed Pharmacother. 2023 Aug;164:114459.(IF=7.5)

3. Jiang N, Zhang Y, Yao C, Liu Y, Chen Y, Chen F, Wang Y, Choudhary MI, Liu X. Tenuifolin ameliorates the sleep deprivation-induced cognitive deficits. Phytother Res. 2023 Feb;37(2):464-476. (IF=7.2)

4. Jiang N, Lv J, Zhang Y, Sun X, Yao C, Wang Q, He Q, Liu X. Protective effects of ginsenosides Rg1 and Rb1 against cognitive impairment induced by simulated microgravity in rats. Front Pharmacol. 2023 Apr 24;14:1167398. (IF=5.6)

5. Zhang Y, Huang H, Yao C, Sun X, He Q, Choudharyc MI, Chen S, Liu X, Jiang N. Fresh Gastrodia elata Blume alleviates simulated weightlessness-induced cognitive impairment by regulating inflammatory and apoptosis-related pathways. Front Pharmacol. 2023 May 3;14:1173920. (IF=5.6)

6. Zhang Y, Sun Y, Liu Y, Liu J, Sun J, Liu X, Fan B, Lu C, Wang F. Polygonum sibiricum polysaccharides exert the antidepressant-like effects in chronic unpredictable mild stress-induced depressive mice by modulating microbiota-gut-brain axis. Phytother Res. 2023 Aug;37(8):3408-3423. (IF=7)

7. Li CC, Ye F, Xu CX, Jiang N, Chang Q, Liu XM, Pan RL. Tryptophan-kynurenine metabolic characterization in the gut and brain of depressive-like rats induced by chronic restraint stress. J Affect Disord. 2023 May 1;328:273-286. (IF=6.6)

8. Dong L, Jiang N, Bai J, Li Y, Song Z, Liu X, Zhang C. Neuroprotective Effects of Dammarane Sapogenins Against lipopolysaccharide-induced Cognitive Impairment, Neuroinflammation and Synaptic Dysfunction. Neurochem Res. 2023 Dec;48(12):3525-3537. (IF=4.2)

9. Xia TJ, Wang Z, Jin SW, Liu XM, Liu YG, Zhang SS, Pan RL, Jiang N, Liao YH, Yan MZ, Du LD, Chang Q. Melatonin-related dysfunction in chronic restraint stress triggers sleep disorders in mice. Front Pharmacol. 2023 Jun 20;14:1210393. (IF=5.6)

10. Jiang N, Zhang Y, Yao C, Chen F, Liu Y, Chen Y, Wang Y, Choudhary MI, Liu X. Hemerocallis citrina Baroni ameliorates chronic sleep deprivation-induced cognitive deficits and depressive-like behaviours in mice. Life Sci Space Res (Amst). 2024 Feb;40:35-43. (IF=2.5)

11. Yang F, Wen H, Ma S, Chang Q, Pan R, Liu X, Liao Y. Icaritin Promotes Myelination by Simultaneously Enhancing the Proliferation and Differentiation of Oligodendrocyte Precursor Cells. Molecules. 2023 Aug 3;28(15):5837. (IF=4.6)

12. Ahmed A, Zeng G, Azhar M, Wang F, Wang J, Fan B, Liu X, Jiang D, Wang Q. Combination of Shengmai San and Radix puerariae ameliorates depression-like symptoms in diabetic rats at the nexus of PI3K/BDNF/SYN protein expression. Animal Model Exp Med. 2023 Jun;6(3):211-220. (IF=3.7)

13. 张亦文,姚彩虹,孙欣然,等.奖励性操作条件反射实验在学习记忆研究中的应用[J].中国实验动物学报,2023,31(06):802-810.

14. 刘雨培,张瑛毓,韦震,等.黄精多糖对睡眠干扰诱导小鼠认知功能损伤的作用及机制研究[J].食品工业科技,2023,44(02):400-407.

15. 张米佳,王孟迪,Ayaz Ahmed,等.模拟失重不同时长对大鼠抑郁样行为的影响（英文）[J].生物化学与生物物理进展,2023,50(02):346-357.

16. Lu C, Wei Z, Jiang N, Chen Y, Wang Y, Li S, Wang Q, Fan B, Liu X, Wang F. Soy isoflavones protects against cognitive deficits induced by chronic sleep deprivation via alleviating oxidative stress and suppressing neuroinflammation. Phytother Res. 2022 May;36(5):2072-2080. (IF=7.2)

17. Jiang N, Zhang Y, Yao C, Huang H, Wang Q, Huang S, He Q, Liu X. Ginsenosides Rb1 Attenuates Chronic Social Defeat Stress-Induced Depressive Behavior via Regulation of SIRT1-NLRP3/Nrf2 Pathways. Front Nutr. 2022 May 12;9:868833.(IF=5.0)

18. Jiang N, Li YJ, Wang MD, Huang H, Chen S, Li Y, Qu L, Wang F, Liu X, Wang Q. The Cognitive-Enhancing Effects of Dendrobium nobile Lindl Extract in Sleep Deprivation-Induced Amnesic Mice. Front Psychiatry. 2022 Jan 19;12:596017. (IF=4.7)

19. Wang H, Huang H, Jiang N, Zhang Y, Lv J, Liu X. Tenuifolin ameliorates chronic restraint stress-induced cognitive impairment in C57BL/6J mice. Phytother Res. 2022 Mar;36(3):1402-1412. (IF=7.2)

20. Huang H, Zhang Y, Yao C, He Q, Chen F, Yu H, Lu G, Jiang N, Liu X. The effects of fresh Gastrodia elata Blume on the cognitive deficits induced by chronic restraint stress. Front Pharmacol. 2022 Aug 29;13:890330. (IF=5.6)

21. Li CC, Ye F, Xu CX, Chang Q, Liu XM, Pan RL. Effect of Radix Polygalae extract on the colonic dysfunction in rats induced by chronic restraint stress. J Ethnopharmacol. 2022 Aug 10;294:115349. (IF=5.4)

22. Ali N, Khan FA, Salawu KM, Irshad R, Jabeen A, Zhang CL, Choudhary MI, Liu XM, Wang Y. Phytochemical Characterizations of Maranthes polyandra (Benth.) Prance. Molecules. 2022 Feb 15;27(4):1316. (IF=4.6)

23. Wang Z, Jin S, Xia T, Liu Y, Zhou Y, Liu X, Pan R, Liao Y, Yan M, Chang Q. Nelumbinis Stamen Ameliorates Chronic Restraint Stress-Induced Muscle Dysfunction and Fatigue in Mice by Decreasing Serum Corticosterone Levels and Activating Sestrin2. J Agric Food Chem. 2022 Dec 28;70(51):16188-16200. (IF=6.1)

24. 张瑛毓,韦震,任梓溢,等.雌马酚(S-equol, Eq)对慢性不可预知温和刺激小鼠抑郁样行为的改善作用[J].大豆科学,2022,41(06):726-732.

25. 姜宁,张亦文,黄红,等.大小鼠学习记忆行为实验方法分类概述[J].中国实验动物学报,2022,30(06):839-845.

26. 姜宁,姚彩虹,叶帆,等.大小鼠焦虑行为实验方法概述[J].中国实验动物学报,2022,30(05):698-704.

27. 于涵,张俊,陈碧清,等.天麻化学成分分类及其药理作用研究进展[J].中草药,2022,53(17):5553-5564.

28. 陈天,胡秦,石哲,等.美国太空动物实验研究发展历程[J].中国实验动物学报,2022,30(04):582-588.

29. 冯利,陈颖,胡晓茹,等.代谢组学在航天医学研究中应用的研究进展[J].中国实验动物学报,2022,30(04):540-546.

30. 刘雨培,张瑛毓,范蓓,等.黄精多糖对模拟航天狭小空间诱导认知功能损伤的改善作用及机制研究[J].中国实验动物学报,2022,30(04):494-503.

31. 董李晋川,黄红,刘斌,等.苏俄太空动物实验研究发展历程[J].中国实验动物学报,2022,30(04):557-567.

32. 姜宁,刘斌,张亦文,等.欧日太空动物实验研究概况[J].中国实验动物学报,2022,30(04):568-573.

33. 黄红,姚彩虹,张亦文,等.失重效应模拟实验方法及对机体功能影响的研究进展[J].中国实验动物学报,2022,30(04):574-581.

34. 陈芳,姜宁,黄红,等.中药防护航天特因环境应激损伤的研究进展[J].中草药,2022,53(12):3811-3820.

35. 夏天吉,闫明珠,王智,等.大小鼠失眠模型和评价方法研究进展[J].中国实验动物学报,2022,30(03):428-435.

36. 魏山山,王孟迪,姜宁,等.人参皂苷Rg1、Rb1、Rg1+Rb1改善东莨菪碱致小鼠认知障碍的作用比较[J].中国比较医学杂志,2022,32(04):94-101.

37. 任梓溢,韦震,姜宁,等.雌马酚对慢性睡眠干扰所致小鼠抑郁样行为的改善作用[J].大豆科学,2022,41(03):323-329.

38. 彭莎,彭壮,胡秦,等.参远苷抑制脂多糖诱导的BV2小胶质细胞炎症机制研究（英文）[J].Digital Chinese Medicine,2022,5(01):75-82.

39. 王孟迪,魏山山,姜宁,等.金钗石斛对MPTP诱导PD小鼠的神经保护作用及机制研究[J].中国比较医学杂志,2022,32(01):48-56.

40. 韦震,宋洪波,安凤平,等.黄精多糖对急性抑郁小鼠模型的改善作用及机制[J].食品工业科技,2022,43(06):351-357.

41. Jiang N, Wang K, Zhang Y, Huang H, Lv JW, Wang Q, Wang HX, Xia TJ, Liu XM. Protective effect of ginsenoside Rb1 against chronic restraint stress (CRS)-induced memory impairments in rats. Behav Brain Res. 2021 May 7;405:113146. doi: 10.1016/j.bbr.2021.113146. Epub 2021 Feb 2.(IF=2.7)

42. Jiang N, Huang H, Zhang Y, Lv J, Wang Q, He Q, Liu X. Ginsenoside Rb1 Produces Antidepressant-Like Effects in a Chronic Social Defeat Stress Model of Depression Through the BDNF-Trkb Signaling Pathway. Front Pharmacol. 2021 Sep 29;12:680903. (IF=5.6)

43. Jiang N, Wei S, Zhang Y, He W, Pei H, Huang H, Wang Q, Liu X. Protective Effects and Mechanism of Radix Polygalae Against Neurological Diseases as Well as Effective Substance. Front Psychiatry. 2021 Dec 17;12:688703. (IF=4.7)

44. Wang Q, Dong L, Wang M, Chen S, Li S, Chen Y, He W, Zhang H, Zhang Y, Pires Dias AC, Yang S, Liu X. Dammarane Sapogenins Improving Simulated Weightlessness-Induced Depressive-Like Behaviors and Cognitive Dysfunction in Rats. Front Psychiatry. 2021 Mar 26;12:638328. (IF=4.7)

45. Lu C, Gao R, Zhang Y, Jiang N, Chen Y, Sun J, Wang Q, Fan B, Liu X, Wang F. S-equol, a metabolite of dietary soy isoflavones, alleviates lipopolysaccharide-induced depressive-like behavior in mice by inhibiting neuroinflammation and enhancing synaptic plasticity. Food Funct. 2021 Jul 5;12(13):5770-5778. (IF=6.1)

46. Lv J, Jiang N, Wang H, Huang H, Bao Y, Chen Y, Liu X. Simulated weightlessness induces cognitive changes in rats illustrated by performance in operant conditioning tasks. Life Sci Space Res (Amst). 2021 May;29:63-71. (IF=2.5)

47. Wang H, Lv J, Jiang N, Huang H, Wang Q, Liu X. Ginsenoside Re protects against chronic restraint stress-induced cognitive deficits through regulation of NLRP3 and Nrf2 pathways in mice. Phytother Res. 2021 May;35(5):2523-2535. (IF=7.2)

48. Zhou Y, Yan M, Pan R, Wang Z, Tao X, Li C, Xia T, Liu X, Chang Q. Radix Polygalae extract exerts antidepressant effects in behavioral despair mice and chronic restraint stress-induced rats probably by promoting autophagy and inhibiting neuroinflammation. J Ethnopharmacol. 2021 Jan 30;265:113317. (IF=5.4)

49. Jiang N, Wang H, Li C, Zeng G, Lv J, Wang Q, Chen Y, Liu X. The antidepressant-like effects of the water extract of Panax ginseng and Polygala tenuifolia are mediated via the BDNF-TrkB signaling pathway and neurogenesis in the hippocampus. J Ethnopharmacol. 2021 Mar 1;267:113625. (IF=5.4)

50. Jiang N, Huang H, Wang H, Lv J, Zeng G, Wang Q, Bao Y, Chen Y, Liu XM. The antidepressant-like effects of Shen Yuan: Dependence on hippocampal BDNF-TrkB signaling activation in chronic social defeat depression-like mice. Phytother Res. 2021 May;35(5):2711-2726. (IF=7.2)

51. Jiang N, Wang H, Huang H, Lv J, Zeng G, Wang Q, Bao Y, Chen Y, Liu X. The Antidepressant-Like Effects of Shen Yuan in a Chronic Unpredictable Mild Stress Rat Model. Front Psychiatry. 2021 Jan 28;12:622204. (IF=4.7)

52. Huang H, Jiang N, Zhang YW, Lv JW, Wang HX, Lu C, Liu XM, Lu GH. Gastrodia elata blume ameliorates circadian rhythm disorder-induced mice memory impairment. Life Sci Space Res (Amst). 2021 Nov;31:51-58. (IF=2.5)

53. Li CC, Gan L, Tan Y, Yan MZ, Liu XM, Chang Q, Pan RL. Chronic restraint stress induced changes in colonic homeostasis-related indexes and tryptophan-kynurenine metabolism in rats. J Proteomics. 2021 May 30;240:104190. (IF=3.3)

54. Sun X, Zhang Y, Li X, Liu X, Qin C. Early-Life Neglect Alters Emotional and Cognitive Behavior in a Sex-Dependent Manner and Reduces Glutamatergic Neuronal Excitability in the Prefrontal Cortex. Front Psychiatry. 2021 Jan 26;11:572224.(IF=4.7)

55. Wang Z, Xia T, Jin S, Liu X, Pan R, Yan M, Chang Q. Chronic Restraint Stress-Induced Muscle Atrophy Leads to Fatigue in Mice by Inhibiting the AMPK Signaling Pathway. Biomedicines. 2021 Sep 26;9(10):1321. (IF=4.7)

56. Wang H, Huang H, Lv J, Jiang N, Li Y, Liu X, Zhao H. Iridoid compounds from the aerial parts of Swertia mussotii Franch. with cytotoxic activity. Nat Prod Res. 2021 May;35(9):1544-1549. (IF=2.2)

57. 姜宁,张亦文,姚彩虹,等.大小鼠抑郁行为实验方法概述[J].中国实验动物学报,2021,29(06):830-838.

58. 王孟迪,姚勤伟,薛涛,等.3种抗抑郁中药方作用比较研究[J].湖南中医药大学学报,2021,41(09):1327-1333.

59. 张亦文,黄红,姚彩虹,等.啮齿类动物触屏操作实验方法研究进展[J].中国药理学与毒理学杂志,2021,35(09):687-688.

60. 黄红,姜宁,张亦文,等.鲜天麻对慢性束缚应激诱导小鼠学习记忆损伤的改善作用[J].中国药理学与毒理学杂志,2021,35(09):653-654.

61. 王智,闫明珠,夏天吉,等.疲劳的动物模型及发生机制研究进展[J].世界科学技术-中医药现代化,2021,23(06):1937-1943.

62. 李杉杉,李汇博,陈善广,等.两种黄花菜组方抗抑郁作用的行为特征比较[J].航天医学与医学工程,2021,34(03):208-213.

63. 高荣静,黄红,姜宁,等.大豆异黄酮对脂多糖诱导小鼠抑郁样行为的改善作用研究[J].大豆科学,2021,40(04):539-545.

64. 《中国应对阿尔茨海默病战略行动计划》建议书[J].科技导报,2021,39(20):149.

65. 李杉杉,刘新民,王琼.基于文献数据库的慢性不可预见性温和应激诱发抑郁症动物模型研究[J].中国比较医学杂志,2021,31(04):77-83.

66. 李玉姣,王海霞,陈善广,等.基于物体认知法研究慢性睡眠干扰对小鼠学习记忆的影响[J].航天医学与医学工程,2021,34(01):25-30.

67. 黄红,吕静薇,陈颖,等.我国中药健康产品管理及市场概况[J].中草药,2021,52(03):902-908.

68. 鲍余,陈颖,曾贵荣,等.人参总皂苷对尾吊模拟微重力大鼠学习记忆损伤和焦虑的保护作用[J].中国实验方剂学杂志,2021,27(07):49-56.

69. 刘思思,乔中全,曾慧杰,等.灰毡毛忍冬转录组SSR位点分析及EST-SSR标记开发[J].分子植物育种,2021,19(09):3015-3021.

70. 刘思思,乔中全,刘新民,等.花蕾型和普通型灰毡毛忍冬花冠开裂过程的转录组比较分析[J].分子植物育种,2021,19(06):1822-1829.

71. Jiang Ning,Lv Jing-Wei, Wang Hai-Xia, Huang Hong, Wang Qiong,Chen Shan-Guang, Qu Li-Na,Alberto Carlos Pires Dias,Liu Xin-Min. Antidepressant-like Effects of Ginsenoside Rg1 in the Chronic Restraint Stress-induced Rat Model[J]. Digital Chinese Medicine,2019,2(4).

72. Jiang N, Lv J, Wang H, Huang H, Wang Q, Lu C, Zeng G, Liu XM. Ginsenoside Rg1 ameliorates chronic social defeat stress-induced depressive-like behaviors and hippocampal neuroinflammation. Life Sci. 2020 Jul 1;252:117669.(IF=6.1)

73. Jiang N, Jingwei L, Wang H, Huang H, Wang Q, Zeng G, Li S, Liu X. Ginsenoside 20(S)-protopanaxadiol attenuates depressive-like behaviour and neuroinflammation in chronic unpredictable mild stress-induced depressive rats. Behav Brain Res. 2020 Sep 1;393:112710. (IF=2.7)

74. Jiang N, Wang H, Lv J, Wang Q, Lu C, Li Y, Liu X. Dammarane sapogenins attenuates stress-induced anxiety-like behaviors by upregulating ERK/CREB/BDNF pathways. Phytother Res. 2020 Oct;34(10):2721-2729. (IF=7.2)

75. Wang H, Jiang N, Lv J, Huang H, Liu X. Ginsenoside Rd reverses cognitive deficits by modulating BDNF-dependent CREB pathway in chronic restraint stress mice. Life Sci. 2020 Oct 1;258:118107. (IF=6.1)

76. Ahmed A, Zeng G, Azhar M, Lin H, Zhang M, Wang F, Zhang H, Jiang D, Yang S, Farooq AD, Choudhary MI, Liu X, Wang Q. Jiawei Shengmai San herbal formula ameliorates diabetic associate cognitive decline by modulating AKT and CREB in rats. Phytother Res. 2020 Dec;34(12):3249-3261. (IF=7.2)

77. Yang Y, Li S, Huang H, Lv J, Chen S, Pires Dias AC, Li Y, Liu X, Wang Q. Comparison of the Protective Effects of Ginsenosides Rb1 and Rg1 on Improving Cognitive Deficits in SAMP8 Mice Based on Anti-Neuroinflammation Mechanism. Front Pharmacol. 2020 Jun 10;11:834. (IF=5.6)

78. Lu C, Lv J, Jiang N, Wang H, Huang H, Zhang L, Li S, Zhang N, Fan B, Liu X, Wang F. Protective effects of Genistein on the cognitive deficits induced by chronic sleep deprivation. Phytother Res. 2020 Apr;34(4):846-858.(IF=7.2)

79. Lu C , Gao R , Lv J , Chen Y , Li S , Zhang L , Zhang N , Wang Y , Fan B , Liu X , Wang F . Neuroprotective effects of soy isoflavones on chronic ethanol-induced dementia in male ICR mice. Food Funct. 2020 Nov 18;11(11):10011-10021. (IF=6.1)

80. Li CC, Jiang N, Gan L, Zhao MJ, Chang Q, Liu XM, Pan RL. Peripheral and cerebral abnormalities of the tryptophan metabolism in the depression-like rats induced by chronic unpredicted mild stress. Neurochem Int. 2020 Sep;138:104771. (IF=4.2)

81. Zhang MD, Tao X, Pan RL, Wang LS, Li CC, Zhou YF, Liao YH, Chen SG, Chang Q, Liu XM. Antidepressant-like effects of cajaninstilbene acid and its related mechanisms in mice. Fitoterapia. 2020 Mar;141:104450. (IF=3.4)

82. Tao X, Yan M, Wang L, Zhou Y, Wang Z, Xia T, Liu X, Pan R, Chang Q. Effects of estrogen deprivation on memory and expression of related proteins in ovariectomized mice. Ann Transl Med. 2020 Mar;8(6):356. (IF=3.6)

83. Tao X, Yan M, Wang L, Zhou Y, Wang Z, Xia T, Liu X, Pan R, Chang Q. Homeostasis Imbalance of Microglia and Astrocytes Leads to Alteration in the Metabolites of the Kynurenine Pathway in LPS-Induced Depressive-Like Mice. Int J Mol Sci. 2020 Feb 21;21(4):1460. (IF=5.6)

84. Williamson EM, Liu X, Izzo AA. Trends in use, pharmacology, and clinical applications of emerging herbal nutraceuticals. Br J Pharmacol. 2020 Mar;177(6):1227-1240. (IF=7.3)

85. Shi Z, Qin M, Huang L, Xu T, Chen Y, Hu Q, Peng S, Peng Z, Qu LN, Chen SG, Tuo QH, Liao DF, Wang XP, Wu RR, Yuan TF, Li YH, Liu XM. Human torpor: translating insights from nature into manned deep space expedition. Biol Rev Camb Philos Soc. 2021 Apr;96(2):642-672. (IF=10)

86. Huang L, Peng Z, Lu C, Chen Y, Lv JW, Qin M, Liao DF, Liu XM, Shi Z. Ginsenoside Rg1 alleviates repeated alcohol exposure-induced psychomotor and cognitive deficits. Chin Med. 2020 May 7;15:44. (IF=4.9)

87. Liu ZW, Jiang N, Tao X, Wang XP, Liu XM, Xiao SY. Assessment of Sexual Behavior of Male Mice. J Vis Exp. 2020 Mar 5;(157).(IF=1.2)

88. Azhar M, Zeng G, Ahmed A, Dar Farooq A, Choudhary MI, De-Jiang J, Liu X. Carnosic acid ameliorates depressive-like symptoms along with the modulation of FGF9 in the hippocampus of middle carotid artery occlusion-induced Sprague Dawley rats. Phytother Res. 2021 Jan;35(1):384-391. (IF=7.2)

89. 党海霞,智恺,刘新民,等.世界卫生组织草药产品注册监管联盟概述[J].中草药,2020,51(23):6133-6136.

90. Ayaz A ,李玉姣 ,李杉杉 , et al.糖尿病所致认知障碍与中药防治概况（英文）[J].生物化学与生物物理进展,2020,47(08):743-761.

91. 吕静薇,姜宁,王海霞,等.基于功能性防护的人参保健食品研究进展[J].人参研究,2020,32(04):45-50.

92. 杨紫玉,杨科,朱晓新,等.黄精保健食品的开发现状及产业发展分析[J].湖南中医药大学学报,2020,40(07):853-859.

93. 王海霞,姜宁,吕静薇,等.开心散抗抑郁、改善学习记忆作用及机制研究进展[J].中草药,2020,51(14):3802-3813.

94. 黄红,陈碧清,姜宁,等.鲜天麻对睡眠干扰诱导小鼠学习记忆障碍的改善作用[J].中草药,2020,51(09):2509-2516.

95. 许腾,王艳,卢聪,等.黄花菜改善模拟微重力所致大鼠抑郁的尿液代谢组学研究（英文）[J].Journal of Chinese Pharmaceutical Sciences,2020,29(03):176-191.

96. Jiang N, Lv JW, Wang HX, Lu C, Wang Q, Xia TJ, Bao Y, Li SS, Liu XM. Dammarane sapogenins alleviates depression-like behaviours induced by chronic social defeat stress in mice through the promotion of the BDNF signalling pathway and neurogenesis in the hippocampus. Brain Res Bull. 2019 Nov;153:239-249. (IF=3.8)

97. Jiang N, Lv JW, Wang HX, Wang Q, Lu C, Yang YJ, Huang H, Xia TJ, Lv GH, Liu XM. Antidepressant-like effects of 20(S)-protopanaxadiol in a mouse model of chronic social defeat stress and the related mechanisms. Phytother Res. 2019 Oct;33(10):2726-2736. (IF=7.2)

98. Liu ZW, Yu Y, Lu C, Jiang N, Wang XP, Xiao SY, Liu XM. Postweaning Isolation Rearing Alters the Adult Social, Sexual Preference and Mating Behaviors of Male CD-1 Mice. Front Behav Neurosci. 2019 Feb 28;13:21. (IF=3)

99. Ahmed A, Zeng G, Jiang D, Lin H, Azhar M, Farooq AD, Choudhary MI, Liu X, Wang Q. Time-dependent impairments in learning and memory in Streptozotocin-induced hyperglycemic rats. Metab Brain Dis. 2019 Oct;34(5):1431-1446. (IF=3.6)

100.Xu T, Lu C, Feng L, Fan LX, Sun J, Fan B, Wang Q, Wang Y, Liu XM, Wang FZ. Liquid chromatography-mass spectrometry-based urinary metabolomics study on a rat model of simulated microgravity-induced depression. J Pharm Biomed Anal. 2019 Feb 20;165:31-40. (IF=3.4)

101.Lu C, Lv J, Jiang N, Wang H, Huang H, Zhang L, Li S, Zhang N, Fan B, Liu X, Wang F. Protective effects of Genistein on the cognitive deficits induced by chronic sleep deprivation. Phytother Res. 2020 Apr;34(4):846-858. (IF=7.2)

102.Peng B, He R, Xu Q, Yang Y, Hu Q, Hou H, Liu X, Li J. Ginsenoside 20(S)-protopanaxadiol inhibits triple-negative breast cancer metastasis in vivo by targeting EGFR-mediated MAPK pathway. Pharmacol Res. 2019 Apr;142:1-13. (IF=9.3)

103.Cong Z, Zhou M, Yang F, Liu C, Pan R, Chang Q, Liu X, Liao Y. Effects of Ganoderma, Rhodiola and grape seed extracts on the glucuronidation and oral bioavailability of resveratrol in rats. Nat Prod Res. 2019 Mar;33(5):767-771. (IF=2.2)

104.Shen S, Zhao M, Li C, Chang Q, Liu X, Liao Y, Pan R. Study on the Material Basis of Neuroprotection of Myrica rubra Bark. Molecules. 2019 Aug 18;24(16):2993. (IF=4.6)

105.Wang LS, Tao X, Liu XM, Zhou YF, Zhang MD, Liao YH, Pan RL, Chang Q. Cajaninstilbene Acid Ameliorates Cognitive Impairment Induced by Intrahippocampal Injection of Amyloid-β1-42 Oligomers. Front Pharmacol. 2019 Sep 24;10:1084. (IF=5.6)

106.Wen H, Xiao W, Biswas S, Cong ZQ, Liu XM, Lam KS, Liao YH, Deng W. Alginate Hydrogel Modified with a Ligand Interacting with α3β1 Integrin Receptor Promotes the Differentiation of 3D Neural Spheroids toward Oligodendrocytes in Vitro. ACS Appl Mater Interfaces. 2019 Feb 13;11(6):5821-5833. (IF=9.5)

107.Zhou Y, Tao X, Wang Z, Feng L, Wang L, Liu X, Pan R, Liao Y, Chang Q. Hippocampus Metabolic Disturbance and Autophagy Deficiency in Olfactory Bulbectomized Rats and the Modulatory Effect of Fluoxetine. Int J Mol Sci. 2019 Sep 1;20(17):4282. (IF=5.6)

108.Zhou YF, Feng L, Liu XM, Tao X, Wang LS, Zhang MD, Wang Z, Chen SG, Chang Q. Urinary metabolic disturbance in the olfactory bulbectomized rats and the modulatory effects of fluoxetine. Life Sci. 2019 Oct 1;234:116751.(IF=6.1)

109.Wang LS, Zhang MD, Tao X, Zhou YF, Liu XM, Pan RL, Liao YH, Chang Q. LC-MS/MS-based quantification of tryptophan metabolites and neurotransmitters in the serum and brain of mice. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Apr 1;1112:24-32. (IF=3)

110.姜宁,吕静薇,王海霞,等.人参皂苷Rg1对慢性束缚应激大鼠模型的抗抑郁作用（英文）[J].Digital Chinese Medicine,2019,2(04):207-218.

111.卜兰兰,金剑,李思迪,等.不同时长睡眠干扰对SD大鼠步态及认知能力的影响[J].中国比较医学杂志,2019,29(11):65-70+115.

112.吕静薇,姜宁,王海霞,等.获得性无助实验方法研究进展[C]//中国实验动物学会.第十五届中国实验动物科学年会论文集.中国医学科学院药用植物研究所;中国航天员科研训练中心人因工程重点实验室;,2019:12.

113.陶雪,张梦荻,王丽莎,等.卵巢摘除对小鼠学习记忆及海马相关蛋白的动态影响[J].神经药理学报,2019,9(04):59-60.

114.周云丰,冯利,陶雪,等.嗅球切除大鼠尿液代谢物的改变和氟西汀的调节作用[J].神经药理学报,2019,9(04):61.

115.姬赐玉,田欢,杨飞飞,等.黄花菜中酚类成分对过氧化氢诱导大鼠嗜铬细胞瘤PC12细胞损伤的保护作用研究[J].世界最新医学信息文摘,2019,19(30):220-222+224.

116.周云丰,陶雪,王丽莎,等.嗅球切除动物模型的特点和应用研究进展[J].药学学报,2019,54(07):1157-1165.

117.黄红,姜宁,吕静薇,等.不同时间睡眠干扰致小鼠体力疲劳模型的建立[J].中国比较医学杂志,2019,29(01):16-20.

118.张梦荻,王丽莎,李晨晨,等.木豆素对慢性不可预见温和应激小鼠的抗抑郁作用[J].中国实验动物学报,2019,27(01):85-90.