研究队伍

副研究员

Email：huangbiling(AT)nbu.edu.cn

研究领域：

核磁共振

分析化学

生命有机磷

个人简介：

黄碧玲，副研究员，硕士生导师。研究方向聚焦于面向核磁共振的氟探针开发及其在手性分析与生物分析中的应用，同时涵盖蛋白质与核苷磷酸化等相关领域。迄今已在Analytical Chemistry、Analytica Chimica Acta、Bioorganic Chemistry、International Journal of Biological Macromolecules 等国际权威期刊发表学术论文20余篇，并已获授权国家发明专利5项。主持国家自然科学基金青年项目1项、宁波市自然科学基金1项，并参与国家自然科学基金基础科学中心项目及重点项目。目前担任Analytical Chemistry、 JACS Au、Journal of Organic Chemistry、International Journal of Biological Macromolecules 等国际期刊审稿人。

教育与科研经历：

2009-2013

山东师范大学，学士

2013-2020

厦门大学，硕士，博士

2020-2022

宁波大学新药技术研究院，助理研究员

2023-至今

宁波大学新药技术研究院，副研究员

科研项目：

国家自然科学青年基金（2022-01 ~ 2024-12），在研

宁波市自然科学基金（2021-08 ~ 2023-7），在研

福建省化学生物学重点实验室（厦门大学）开放基金（2021-01 ~ 2022-12），已结题

代表性论文（2022至今）：

1. Biling Huang*, Shuyi Lu, Qian Wu, Yan Liu. Recent Advances in Spectroscopic Chiral Analysis of Carboxylic Acids. Talanta. 2026, 299, 129155.

2. Shuyi Lu, Qian Wu, Shanshan Wang*, Dongru Sun*, Yan Liu, Shaohua Huang, Biling Huang*. 19F NMR-Guided Chiral Analysis and Machine Learning for Absolute Configuration Prediction of Carboxylic Acids. Analytical Chemistry. 2025, 97, 41, 22986–22994.

3. Qian Wu, Shuyi Lu, Chao Zhang, Wenda Zhong, Hua Zhao, Yufen Zhao*, Biling Huang*. Significant impacts of metal ions from ancient oceans on nucleoside phosphorylation. BMC chemistry 2025, 19 (1), 252.

4. Xijian Wu, Xin Tong, Biling Huang, and Shaohua Huang. Novel Pseudo-Two-Dimensional 19F NMR Spectroscopy for Rapid Simultaneous Detection of Amines in Complex Mixture. Analytical Chemistry. 2024, 96(42):16818-16824.

5. Biling Huang*, Shuyi Lu, Fulai Li. A difunctional NMR & CD probe for specific detection and enantiomeric recognition of biothiols in complex mixtures. Analytica Chimica Acta. 2024, 1328, 343186.

6. Ming-Xiao Zhao, Ruo-Fan Ding, Qiang Chen, Junhua Meng, Fulai Li, Songsen Fu, Biling Huang, Yan Liu, Zhi-Liang Ji*, Yufen Zhao*. Nphos: Database and Predictor of Protein N-phosphorylation. Genomics, Proteomics & Bioinformatics. 2024, qzae032.

7. Lihua Xu; Yan Liu; Songsen Fu*; Yufen Zhao; Shaohua Huang*; Biling Huang*. 19F NMR Enantiodiscrimination and Diastereomeric Purity Determination of Amino Acids, Dipeptides, and Amines. Analyst. 2023, 148(18), 4548-4556.

8. Runjin Zhao, Biling Huang, Gang Lu, Songsen Fu*, Jianxi Ying* and Yufen Zhao. A Practical Method for Amino Acid Analysis by LC-MS Using Precolumn Derivatization with Urea. International Journal of Molecular Sciences. 2023, 24(8), 7332.

9. Mingxiao Zhao, Qiang Chen, Fulai Li, Songsen Fu, Biling Huang, Yufen Zhao*. Protein phosphorylation database and prediction tools. Briefs in Bioinformatics. 2023, 24(2), 1-20.

10. 傅松森，李福来，黄碧玲，蔡华欢，倪锋，应见喜，刘艳，付川，高祥，李艳梅，赵玉芬*，基于N-磷酰化氨基酸探讨激酶磷转移机制，中国科学：化学，2023, 53(3): 338-348.

11. Lihua Xu; Biling Huang*; Zhiying Hou; Shaohua Huang*; Yufen Zhao*. Solvent Effects Used for Optimal Simultaneous Analysis of Amino Acids via 19F NMR Spectroscopy. Analytical Chemistry. 2023, 95(5): 3012-3018.

12. Biling Huang*; Lihua Xu; Jianxi Ying; Yufen Zhao; Shaohua Huang*. A Novel In-situ Strategy for Enantiomeric Discrimination and Selective Identification of Multicomponent Carboxylic Acids in Foods. Analytica Chimica Acta. 2022, 1230, 340402. 

13. Biling Huang*; Lihua Xu; Zhao Zhao; Ning Wang; Yufen Zhao; Shaohua Huang*. Simultaneous analysis of amino acids based on discriminative 19F NMR spectroscopy. Bioorganic Chemistry. 2022, 124, 105818.

14. Biling Huang*; Lihua Xu; Ning Wang; Jianxi Ying; Yufen Zhao; Shaohua Huang*. trans-4-Fluoro-l-proline: A Sensitive 19F NMR Probe for the Rapid Simultaneous Enantiomeric Analysis of Multicomponent Amines. Analytical Chemistry. 2022, 97(3): 1867-1873.

发明专利：

1. ZL2210561533.1

2. ZL202111637551.5

3. ZL202110253181.9

4. ZL202110238438.3

5. ZL202010823990.4