研究队伍

副研究员

Email：gaoxinchang(AT)nbu.edu.cn

研究领域：

肽类药物设计与筛选研究；红枣等药食同源活性成分与健康功能效应研究

个人简介：

主要研究领域为活性成分的筛选设计和代谢研究，完成了多种食品原料及加工过程后的活性成分分析工作，完成了三种国家一类新药临床前后的体内外吸收代谢研究工作。

教育与科研经历：

1998.09-2002.06

石河子大学，食品科学与工程，本科

2008.03-2011.03

华东理工大学，制药工程，硕士

2020.09-2023.06

清华大学，化学，博士

2024.07-至今

宁波大学新药技术研究院，副研究员

代表性论文：

1. Xiong Yong zhao, Gao Xinchang*, Pan Daodong, Zhang Ting, Qi Lulu, Wang Ning, Zhao Yufen, Dang Yali*. A strategy for screening novel umami dipeptides based on common feature pharmacophore and molecular docking. Biomaterials. 2022; 288:121697. doi: 10.1016/j.biomaterials.2022.121697.

2. Qi Lulu, Gao Xinchang*, Pan Daodong, Sun Yangying, Cai Zhendong, Xiong Yongzhao, Dang Yali*. Research progress in the screening and evaluation of umami peptides. COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY（IF: 14.8, 大小区1区，TOP期刊）. 2022;21(2):1462-90. doi: 10.1111/1541-4337.12916.

3. Pei Jingyan, Liu Zhu, Pan Daodong, Zhao Yufen, Dang Yali*, Gao Xinchang*. Transport, Stability, and In Vivo Hypoglycemic Effect of a Broccoli-Derived DPP-IV Inhibitory Peptide VPLVM. Journal of Agricultural and Food Chemistry（IF: 6.1, 大区1区，小区2区，TOP期刊）. 2022;70(16):4934-41. doi: 10.1021/acs.jafc.1c08191.

4. Lulu Qi, Jialuo Du, Yue Sun, Yongzhao Xiong, Xinyao Zhao, Daodong Pan, Yueru Zhi, Yali Dang*, Xinchang Gao*. Umami-MRNN: Deep learning-based prediction of umami peptide using RNN and MLP. Food Chemistry（IF: 8.8, 大小区1区，TOP期刊）, 2022.11,405. DOI:10.1016/j.foodchem.2022.134935

5. Xiangning Xie, Yali Dang*, Pan Daodong, Yangying Sun, Changyu Zhou, Jun He, Xinchang Gao*. The enhancement and mechanism of the perception of saltiness by umami peptide from Ruditapes philippinarum and ham. Food chemistry（IF: 8.8, 大小区1区，TOP期刊）, 2022.11, 405. doi: 10.1016/j.foodchem.2022.134886

6. Chen Li, Ying Hua, Daodong Pan, Lulu Qi, Chaogeng Xiao, Yongzhao Xiong, Wenjing Lu, Yali Dang*, Xinchang Gao*, Yufen Zhao. A rapid selection strategy for umami peptide screening based on machine learning and molecular docking. Food Chemistry（IF: 8.8, 大小区1区，TOP期刊）, 2022.10,404.

7. Jingyan Pei, Xinchang Gao*, Daodong Pan, Ying Hua, Jun He, Zhu Liu*, Yali Dang*. Advances in the stability challenges of bioactive peptides and improvement strategies. Current Research in Food Science（IF: 6.3, 大区2区，小区2区）, 2022.11, 5: 2162-2170

8. Chen Mengdi, Pan Daodong, Zhou Tianqiong, Gao Xinchang*, Dang Yali*. Novel Umami Peptide IPIPATKT with Dual Dipeptidyl Peptidase-IV and Angiotensin I-Converting Enzyme Inhibitory Activities. Journal of Agricultural and Food Chemistry（IF:5.895, 大区1区，小区2区，TOP期刊）. 2021;69(19):5463-70. doi: 10.1021/acs.jafc.0c07138.

9. Zhang Yue, Pan Daodong, Yang Zhengcang, Gao Xinchang*, Dang Yali*. Angiotensin I-Converting enzyme (ACE) inhibitory and dipeptidyl Peptidase-4 (DPP-IV) inhibitory activity of umami peptides from Ruditapes philippinarum. LWT-FOOD SCIENCE AND TECHNOLOGY（IF:6.056, 大区2区，小区2区，TOP期刊）. 2021;144. doi: 10.1016/j.lwt.2021.111265.

10. Zhou Tingyi, Liu Zhu, Pei Jingyan, Pan Daodong, Gao Xinchang*, Dang Yali*, Zhao Yufen*. Novel Broccoli-Derived Peptides Hydrolyzed by Trypsin with Dual-Angiotensin I-Converting Enzymes and Dipeptidyl Peptidase-IV-Inhibitory Activities. Journal of Agricultural and Food Chemistry（IF:5.895, 大区1区，小区2区，TOP期刊）. 2021; 69(37):10885-92. doi: 10.1021/acs.jafc.1c02985.

11. Shang Yan, Zhang Wenbin, Dang Yali*, Gao Xinchang*. Physical properties and functional characteristics of broccoli-soluble dietary fiber. Food Bioscience（IF:5.2, 大区2区，小区2区）. 2023; 103272 (56). doi.org/10.1016/j.fbio.2023.103272.