研究队伍

Post-doctor

shakir(AT)nbu.edu.cn; shakirkharal(AT)gmail.com

 Research areas/interests：

Neuroprotection

Neurobiology

Pathobiology of infectious agent, host immune responses, and disease diagnosis

Personal Brief Introduction：

I am a pathologist with PhD in pathology, research interests in pathobiology of infectious agent, host immune responses, and disease diagnosis. My current research focuses neuroprotection of brain diseases through Chinese herbal medicine using animal’s models. I’m working on C. elegans and mice model to check the neuroprotection of Parkinson’s disease. Previously my work was on modulation of host innate immune responses to counteract the avian bacterial disease particularly Salmonella gallinarum. I have experience in fundamental pathobiological and immunological techniques i.e. isolation and molecular characterization of pathogens from food and animal sources, disease diagnosis via molecular and immunological assays, in vitro antiviral assays. I have more than nine publications and two book chapters in national and international impact factor journals. My research aims to explore the biology of host-agent relationship with particular focus bacterial diseases, their recognition by host pattern recognition receptors, host innate immune factors that limit the virus replication and gene regulation. The long-term goal of my research is to develop preventive and therapeutic approaches to control infections.

Education and research experience：

2009-2014

University of Agriculture, Faisalabad, Pakistan. Doctor of Medicine.

2014-2016

University of Agriculture, Faisalabad, Pakistan. M. Phil Pathology.

2016-2023

University of Agriculture, Faisalabad, Pakistan. Ph.D. Pathology.

2023-At present

Ningbo University, Institute of Drug Discovery Technology. Post-doctor research

Funding and Projects：

Indigenous PhD Fellowship, Higher Education Commission (HEC) Pakistan (2017-2023)

Representative Papers：

1. Muhammad Wasim Usmani, Farzana Rizvi, Muhammad Kashif Saleemi, Muhammad Zishan Ahmad, Muhammad Numan, Muhammad Zulqarnain Shakir, Nasir Mahmood, and Jahanzeb Tahir, 2023. A study of the immunomodulatory effects of coconut oil extract in broilers experimentally infected with velogenic Newcastle disease virus. Accepted (ABS23-0489) in Animal Bioscience. (IF=2.20)

2. Muhammad Shahzad Shafiq, Farzana Rizvi, Al-Hafiza Shafia Tehseen Gul, Muhammad Imran Arshad, Muhammad Wasim Usmani, Ayesha Ramzan, Muhammad Zulqarnain Shakir and Nasir Mahmood, 2023. Bovine babesiosis: Insights into the global perspective for disease control. Accepted (ACTROP-D-23-01256) in Acta Tropica. (IF=2.83)

3. Nouman Amjad*, Farzana Rizvi,* Muhammad Zulqarnain Shakir, Muhammad Wasim Usmani, Muhammad Rehan Amjad and Muhammad Afnan Khalid. 2023. In vivo concurrent efficacy of purified Immunoglobulins and Licorice (Glycyrrhiza glabra) root extracts against Newcastle Disease Virus. Pak. J. Agri. Sci., Vol. 59(6), 985-992; 2022. DOI:10.21162/PAKJAS/22.874 (IF=1.054), Q3, HEC=W

4. Iqra Asghar¹, Farzana Rizvi*, Muhammad Wasim Usmani, Muhammad Zulqarnain Shakir, Nasir Mahmood, Muhammad Numan, Muhammad Sohaib Ikram and Namra Waqar. 2022. Immunomodulatory Effect of Turmeric (Curcuma longa) in Escherichia coli Induced Infected Broiler Chicks. J Microb Path, Volume 6:5, 2022. (IF=0.16)

5. MZ Shakir, F Rizvi, MT Javed, MI Arshad, 2021 Seroprevalence and pathological studies of Salmonella infection in commercial white layer birds. Microbial Pathogenesis, 159: 159-170 2. (IF=3.79)

6. Muhammad Zulqarnain Shakir, Farzana Rizvi*, Muhammad Kashif Saleemi, Muhammad Wasim Usmani, Nasir Mahmood, Faisal Rasheed Anjum, Nouman Amjad, Muhammad Shahzad Shafique and Ayesha Ramzan. 2022. Molecular Detection of Salmonella gallinarum and its Prevention using Autogenous Bacterin in White Crystal Neck Commercial Layer Birds. J Microb Path, Volume 6:1, 2022. (IF=0.16)

7. Anjum FR*, Anam S, ur Rahman S, Ali S, Aslam MA, Rizvi F, Asif M, Abdullah RM, Abaidullah M, Shakir MZ, Goraya MU. Anti-chicken type I IFN countermeasures by Major Avian RNA Viruses. Virus research. 2020 Jun 16:198061. (IF=5.00)

8. S. Nawaz, M. Asif , Z.A. Bhutta , M.F. Kulyar , R. Hussain , A. Ramzan , S. Shafeeq , M.Z. Shakir , M.T. Sarfaraz and K. Li, 2021, A comprehensive review on acute phase proteins in chicken. DOI: 10.1399/eps.2021.344 . (IF=2.2)

9. Naveed G, Ehtisham-ul-Haque S, Khan I, ur Rahman S, Anam S, Usman M, Shakir MZ, Naveed A, Abbas G, Anjum FR*. Enhancement in humoral response against inactivated Newcastle disease vaccine in broiler chickens administered orally with plant-derived soyasaponin. Poultry Science. 2020 Feb 27. (IF=4.4)

Book chapters：

1. Faisal Rasheed Anjum, Sidra Anam, Muhammad Luqman, Ameena A. AL-surhanee, Abdullah F. Shater, Muhammad Wasim Usmani, Sajjad ur Rahman, Muhammad Sohail Sajid, Farzana Rizvi and Muhammad Zulqarnain Shakir 2021, Fungal Immunology: Mechanisms of Host Innate Immune Recognition and Evasion by Pathogenic Fungi. DOI: 10.5772/intechopen.101415.

2. Muhammad Wasim Usmani, Farzana Rizvi, Muhammad Zulqarnain Shakir, NasirMahmood, Muhammad Numan, Rana Muhammad Abdullah, Jahanzeb Tahir, Muhammad Shahzad Shafiq and Hafiz ahmad hameed. Factors Influencing the Emergence and Re-emergence of Zoonotic Infectious Diseases in Livestock and Human Populations. DOI: 10.47278/book.zoon/2023.023

Nucleotide/Gene sequence/NCBI/GenBanK：

1. Shakir, M.Z., Rizvi, F., Arshad, M.I., Mahmood, N. and Usmani, M.W. Salmonella enterica subsp. enterica serovar Gallinarum isolate MZS1 glucose-1-phosphate adenylyl transferase (glgC) pseudogene, partial sequence. MW550075 (249bp, DNA linear).

2. Mahmood, N., Rizvi, F., Saleemi, M.K., Shakir, M.Z. and Usmani, M.W. Salmonella enterica subsp. enterica serovar Pullorum isolate NM1 glucose-1-phosphate adenylyl transferase (glgC) pseudogene, partial sequence. MW550074 (249bp, DNA linear).

 Abstract Published：

1. Farzana Rizvi, Muhammad Wasim Usmani, Muhammad Shahzad Shafiq, Ayesha Ramzan, Faiza Wattoo, Muhammad Zulqarnain Shakir and Nasir Mahmood. Traditional Medicine and Biodiversity: A Relationship between Disease and Environment. Symposium on Animal Welfare and One Health. 1st IS-AW & Oh -2022, 21st- 22nd May 2022. Organized by Shaheed Benazir Bhutto University of Veterinary and Animal Science, Sakrand.

2. Rizvi F, Ayesha Ramzan, M. Wasim Usmani, M. Zulqarnain Shakir, Nasir Mahmood, Raja Zabeeh Ullah Khan, Shah Nawaz, M. Shahzad Shafiq and Muhammad Nasir, 2019. Effects of Single or Combined Dietary Supplementation of β-Glucan and Aleo Vera on Growth Performance, Blood characteristics and Meat Quality in Broilers. International Conference on Food Processing and Entrepreneurship 2019, January 29-30.

3. Rizvi F, M. Farooq, M. Zulqarnain Shakir, Nasir Mahmood, M. Wasim Usmani, Shah Nawaz, and M. Shahzad Shafiq, 2019. Effects of Aqueous Extract of Olive Leaves on Immunity, Growth Performance, Blood characteristics and Meat Quality in Broilers. International Conference on Food Processing and Entrepreneurship 2019, January 29-30.

4. M. Farooq, Farzana Rizvi, M. Zulqarnain Shakir, M. Wasim Usmani, Sadaf Fiaz, M. Shahzad Shafiq, Ayesha Ramzan and M. Sajid, 2019. Immune modulation by aqueous extract of olive leaves in Escherichia Coli infected broiler chicks. 1st National Conference on Microbiology of Infectious Diseases and Health Safety, University of Swabi, April 3-5, pp: 41.

5. Iqra Muzzafar, Farzana Rizvi, Nasir Mahmood, M. Wasim Usmani, M. Zulqarnain Shakir, Sadaf Faiz, Ayesha Ramzan and Shah Nawaz, 2019. Antiviral effect of aqueous extract of Aloe Vero (Aloe barbadensis) in Newcastle Disease infected broiler chicks. 1st National Conference on Microbiology of Infectious Diseases and Health Safety, University of Swabi, April 3-5, pp: 105.

6. Farzana Rizvi, M. Numan, M. Wasim Usmani, M. Zulqarnain Shakir, Nasir Mahmood, M. Jawad Iqbal and Muhammad Sajid, 2019. National Camel Conference (Health, Reproduction, Production and Products), University of Agriculture Faisalabad, Pakistan, June 25, pp: 07.

7. Farzana Rizvi, M. Numan, M. Zishan Ahmad, M. Wasim Usmani, Nasir Mahmood, M. Zulqarnain Shakir, Ayesha Ramzan, M. Jawad Iqbal and M. Sajid, 2019. Molecular Detection and Preventive Tools of Buffalopox virus (BPXV) in Large Ruminants in Punjab, Pakistan. 3rd National Conference on Emerging Trends in Bioinformatics & Biosciences, Dept. of Bioinformatics, Hazara University Mansehra, October 03-05, pp: 47.

8. Farzana Rizvi, Qaiser Amin, Nasir Mahmood, M. Wasim Usmani, M. Zulqarnain Shakir, M. Shahzad Shafiq, Shahnawaz and Ahmad Abbas, 2019. Vaccination of Foot and Mouth disease using Nanoparticles. 3rd National Conference on Emerging Trends in Bioinformatics & Biosciences, Dept. of Bioinformatics, Hazara University Mansehra, October 03-05, pp: 105.

9. Ali Hassan, Farzana Rizvi, MK Saleemi, Razia Kausar, Nasir Mahmood, M. Wasim Usmani, M. Zulqarnain Shakir, Shah Nawaz and Ayesha Ramzan, 2018. Antiviral action of Aqueous Extract of Ocimum sanctum Leaves in Newcastle Disease Virus Infected Broiler Chicks. International Poultry Science Summit: Shandong Vocational Animal Science and Veterinary College, Weifang, China, pp: 33.

10. M. Wasim Usmani, Farzana Rizvi, M. Kashif Saleemi, Nasir Mahmood, M. Zulqarnain Shakir and Sadaf Faiz, 2017. Lauric acid as immune modulatory agent against Newcastle disease virus. Proceeding of 2nd International Symposium on Advances in Molecular Biology of Plants and Health Sciences, 21-23 November, CEMB, Lahore, Pakistan, pp:17.