手性药物分离分析团队

黄少华

发布时间:2025-03-26  作者:  点击量:

 

黄少华 博士 Ph. D.

教授 Professor

Email:huangshaohua(AT)nbu.edu.cn

学科方向 Discipline:

分析化学 Analytical Chemistr

药物分析 Pharmaceutical Analysis




个人简介 Personal Introduction:

黄少华 博士 研究员 博士生导师,中国科学院“关键技术人才”计划入选者(2015),宁波市“泛3315计划”创新个人(2019),宁波市人才(2021)。现任宁波大学新药技术研究院副院长、新药技术研究院核磁共振中心主任、手性药物分离分析课题组负责人。课题组致力于药物化学相关研究工作,以新药发现为目标,以特色的(功能分离)材料、(先进谱学)方法和(智能化制药)装备为支撑。近期研究重点针对手性药物、特别是手性天然产物的药用开发,发展新型功能分离材料,并对候选活性分子进行结构、药物-靶标相互作用的谱学鉴定研究工作。课题组先后承担了多项国家自然科学基金、省部级科研装备研发等项目,在Angew. Chem. Int. Ed., J. Am. Chem, Soc.等重要学术期刊发表SCI论文60余篇,申请发明专利18项,获得授权9项。现任《波谱学杂志》和《Magnetic Resonance Letters》编委以及多个国际学术期刊的特邀审稿人。


教育与工作经历 Education and Professional Experience:

2018-至今           宁波大学新药技术研究院,药物分析,教授,博士生导师

                                    Professor in Analytical Chemistry/Pharmaceutical Analysis, 

                                    Institute of Drug Discovery Technology, Ningbo University

2008-2018          中国科学院青岛生物能源与过程研究所,分析化学,助理研究员/副研究员/研究员

                                    Assistant Professor/Associate Professor/Full Professor in Analytical Chemistry,

                                    Qingdao Institute of Bioenergy and Bioprocess Technology, 

                                    Chinese Academy of Sciences

2005-2008          中国科学院武汉物理与数学研究所,分析化学,博士

                                    Ph. D. in Analytical Chemistry, Wuhan Institute of Physics and Mathematics,

                                    Chinese Academy of Sciences

2002-2005          武汉工程大学化工与制药学院,应用化学,硕士

                                    Master Degree in Applied Chemistry, School of Chemical Engineering and Pharmacy,

                                    Wuhan Institute of Technology

1998-2002          江苏恩华药业集团徐州第三制药厂,技术员

                            Technologist, The 3rd Pharmacy Factory, Xuzhou Nhwa Pharm.

                            Group Lit. Corp., Jiangsu Province, PR China

1995-1998          武汉工程大学化工系,有机化学工艺,学士

                                    B. S. Degree in Chemical Technology, Department of Chemical Engineering, 

                                    Wuhan Institute of Technology



研究方向 Research Interests:

1. 手性分离分析技术 Chiral Separation Analysis Techniques

l 新型手性分离材料 Novel chiral stationary phases (CSPs)

l 手性色谱技术 Chiral HPLC technology

l 绿色手性药物拆分技术 Green chiral drug resolution technology

l 手性核磁技术 Chiral NMR technology

2. 手性分析及中药质量控制方法 Chiral Analysis and QC of Traditional Chinese medicines

l 手性分子稳定性、保护及机理研究 

Stability and protection of chiral molecules and their mechanisms

l 天然产物(中药)质量控制方法 

Quality control methods of natural products (traditional Chinese medicines)

3. 生命同手性起源 Origin of Homochirality of Life

l 分子对称性破缺及机理研究 Molecular symmetry breaking and its mechanism

l 手性扩增及机理研究 Chiral amplification and its mechanism

l 手性转移及机理研究 Chiral transfer and its mechanism


科研项目 Research Grants:

1. 新疆科技厅重大科技专项项目,2023A02010,红枣加工品质提升技术集成与功能性产品开发,2024/01-2026/12,在研,主持

2. 国家自然科学基金面上项目,22174080,纳米基质辅助的高分辨手性核磁共振色谱及结构与性能的关系,2022/01-2025/12,在研,主持

3. 空间站科学实验项目,手性分子辐射响应行为研究,2022/12-2024/12,在研,主持

4. 宁波市科技计划项目,2021S087,潜在生物标记物D-氨基酸的高通量检测,2021/06-2024/05,已结题,主持

5. 天体化学与空间生命-钱学森空间科学协同研究中心科技项目,2021001,空间环境下手性稳定性研究,2021/01-2022/12,已结题,主持

6. 中国科学院“关键人才项目”(2015年),多糖类大分子改性及其在分离领域中的应用,2016/01-2018/12,已结题,主持

7. 国家自然科学基金青年项目,21105108,基于虚拟‘色谱固定相’的NMR 中色谱技术及其分离性能研究,2012/01-2014/12,已结题,主持


荣誉奖励 Awards:

1. 2022年度宁波大学“优秀职工”

2. 2016年度中国科学院青岛生物能源与过程研究所十周年“十佳职工提名奖”

3. 2016年度青岛市“优秀共产党员”提名

4. 2016年度中国科学院青岛生物能源与过程研究所“优秀共产党员”


人才工程 Talent Programs:

1. 2021年入选宁波市“拔尖人才”计划

2. 2019年入选宁波市“泛3315计划”创新个人

3. 2016年入选中国科学院海洋区域中心“技术能手”计划

4. 2015年入选中国科学院“关键技术人才”计划


学术兼职 Academic Service and Committees:

1. 《Magnetic Resonance Letters》编委(2021-2025)

2. 《波谱学杂志》青年编委 (2018-2025)

3.  浙江省分析测试学会磁共振专业委员会副主任 (2023至今)


 主讲课程 Teaching Experience:

1. 波谱分析 Spectroscopic Analysis

2. 药物分析 Pharmaceutical Analysis


邀请报告 Invited Presentations:

1. Wu Xijian, Huang Shaohua*, Development and Application of Multi component Simultaneous Identification and Analysis Method for Complex Systems Based on 19F NMR, The 34th Annual Conference of the Chinese Chemical Society, 2024, Guangzhou, China (Oral presentation)

2. Sun Shanshan, Guo Dandan, Huang Shaohua*, and Zhao Yufen, Chiral amplification of amino acids driven by clay minerals in the early Earth microenvironment, Origins2023, ISSOL, 2023, Ecuador (Oral presentation)

3. Huang Shaohua*, A New Drug Analysis Method based on NMR Spectroscopy and its Applications, Proceedings of the 4th Zhejiang Marine Drug Academic Conference, 2018, Ningbo, China (Oral presentation)

4. Yang Ying and Huang Shaohua*, NMR Spectral Simplification Using Ionic-Liquid Coated Silica Nanoparticle, Proceedings of the 19th National Magnetic Resonance Conference, 2016, Lanzhou, Invited speaker. (Oral presentation)

5. Yang Ying, Wang Limin, and Huang Shaohua*, Matrix assisted chromatographic NMR spectroscopy and its applications. Proceedings of International 18th Beijing Conference and Exhibition on Instrumental Analysis, 2015 Beijing, China. Keynote speaker (Oral presentation)

6. Huang Shaohua*, Matrix assisted chromatographic NMR spectroscopy (CNMR), Proceedings of the 18th National Magnetic Resonance Conference, 2014, Hangzhou, China (Oral presentation)

7. Yang Ying and Huang Shaohua*, NMR Spectral Simplification Using Ionic-Liquid Coated Silica Nanoparticle, Proceedings of the 19th National Magnetic Resonance Conference, 2016, Lanzhou, Invited speaker. (Oral presentation)

8. Huang Shaohua*, A New Drug Analysis Method based on NMR Spectroscopy and its Applications, Proceedings of the 4th Zhejiang Marine Drug Academic Conference, 2018, Ningbo, China (Oral presentation)


论文列表 Publications (近五年):

1. Han, B.; He, J.; Huang, S. Chiral recognition of some D and L-amino acids by microcrystalline cellulose assisted diffusion-ordered NMR spectroscopy. Journal of Magnetic Resonance Open 2025. DOI: 10.1016/j.jmro.2025.100189.

2. Min, Z.; Dandan, G.; Yan, Z.; Shaohua, H. Controllable preparation and application of mixed-mode stationary phases based on green peptide coupling reactions. Microchemical Journal 2025. DOI: 10.1016/j.microc.2025.113347.

3. Xin Tong, Xijian Wu, Xing Zhang, Shaohua Huang*, Zhen Wu*. A novel chiral amino acid-based methodology for authenticity and origin determination of Chinese wines, ACS Food Science & Technology 2024, 4: 2675-2681.

4. Xijian Wu, Xin Tong, Biling Huang, Shaohua Huang*. Novel pseudo-two-dimensional 19F NMR spectroscopy for rapid simultaneous detection of amines in complex mixture, Analytical Chemistry 2024, 96:16818-16824.

5. Qi Xiao, Dandan Guo*, Jing He, Min Zhang, Shan He*, Shaohua Huang*, Preparation and chromatographic evaluation of 9-oxa-10-phosphophenanthrene 10-oxide bonded phenyl stationary phase and investigation of its retention mechanism through NMR, Analytica Chimica Acta 2024, 1311, 342735.

6. Chuan Chen, Zheng Cao, Hehua Lei, Cui Zhang, Mengjing Wu, Shaohua Huang, Xinzhi Li, Denghui Xie, Maili Liu, Limin Zhang*, Gang Chen*, Microbial Tryptophan Metabolites Ameliorate Ovariectomy‐Induced Bone Loss by Repairing Intestinal AhR‐Mediated Gut‐Bone Signaling Pathway, Advanced Science 2024, 11, 2404545.

7. Shuang Li, Xuming Sha, Shanshan Sun, Xing Zhang, Dandan Guo*, Shaohua Huang*, Study on the stability of molecular chirality and the configuration protection of dihydromyricetin in vine tea, Journal of Food Science 2024, 89, 3569-3576.

8. Yujing Zhu, Xiaoju Shi, Duanxiu Li, Shuang Li, Lin Wang, Zongwu Deng, Shaohua Huang, Hailu Zhang*, Sustained release of matrine via salt formation with hesperetin, CrystEngComm 2024, 26, 1090-1098.

9. Dandan Guo*, Nadeem Muhammad, Shuxin Yu, Jinhui Wang, Shaohua Huang*, Yan Zhu*, Polyamidoamine Dendrimers Functionalized Water-Stable Metal–Organic Frameworks for Sensitive Fluorescent Detection of Heavy Metal Ions in Aqueous Solution, Polymers 2023, 15, 3444.

10. Xiaoqian Zhou, Dandan Guo*, Shaohua Huang*, Yufen Zhao*, A green, efficient and economical polypeptide—modified bamboo fiber and its application in glycopeptide antibiotics adsorption, Cellulose 2023, 30, 5201-5215.

11. Lihua Xu, Biling Huang*, Zhiying Hou, Shaohua Huang*, Yufen Zhao*, Solvent Effects Used for Optimal Simultaneous Analysis of Amino Acids via 19F NMR Spectroscopy, Analytical Chemistry 2023, 95, 3012-3018.

12. Lihua Xu, Qiong Wang, Yan Liu, Songsen Fu, Yufen Zhao, Shaohua Huang*, Biling Huang*, 19 F NMR enantiodiscrimination and diastereomeric purity determination of amino acids, dipeptides, and amines, Analyst 2023, 148, 4548-4556.

13. 章慧*,刘新玲,南子昂,沙旭明,张仕林,黄少华,苏纪豪,赵玉芬,火星探测和天体矿物手性,大学化学 2023, 38(2), 116-131.

14. Biling Huang*, Lihua Xu, Jianxi Ying, Yufen Zhao, Shaohua Huang*. A novel in-situ strategy for enantiomeric discrimination and selective identification of multicomponent carboxylic acids in foods. Analytica Chimica Acta 2022, 1230: 340402.

15. Dandan Guo, Xiaoqian Zhou, Shaohua Huang*, Yan Zhu*. Enantioselective fluorescent detection of lysine enantiomers by functionalized achiral metal organic frameworks. Microchemical Journal 2022, 181: 107666.

16. Biling Huang*, Lihua Xu, Zhao Zhao, Ning Wang, Yufen Zhao, Shaohua Huang*. Simultaneous analysis of amino acids based on discriminative 19F NMR spectroscopy. Bioorganic Chemistry 2022, 124: 105818.

17. Dandan Guo, Xiaoqian Zhou, Nadeem Muhammad, Shaohua Huang*, Yan Zhu*. An overview of poly (amide-amine) dendrimers functionalized chromatographic separation materials. Journal of Chromatography A 2022, 1669: 462960.

18. Jianxi Ying, Ruiwen Ding, Yumeng Zhang, Bowen Han, Yeting Guo, Ning Wang, Dandan Guo, Yile Wu, Junwei Huang, Yan Liu, Feng Ni, Shaohua Huang*, Yufen Zhao*. Trimetaphosphate-induced chiral selection between amino acid and nucleoside using 15N-31P coupling NMR. Chinese Chemical Letters 2022, 33: 821-824.

19. Biling Huang*, Lihua Xu, Ning Wang, Jianxi Ying, Yufen Zhao, Shaohua Huang*. trans-4-Fluoro-l-proline: A Sensitive 19F NMR Probe for the Rapid Simultaneous Enantiomeric Analysis of Multicomponent Amines. Analytical Chemistry 2022, 94: 1867-1873.

20. Shuxin Yu, Xuming Sha, Xiaoqian Zhou, Dandan Guo*, Bowen Han, Shaohua Huang*, Yan Zhu. Cyclodextrin-dendrimers nanocomposites functionalized high performance liquid chromatography stationary phase for efficient separation of aromatic compounds. Journal of Chromatography A 2022, 1662: 462730.

21. Dandan Guo, Shaohua Huang*, Yan Zhu*. The Adsorption of Heavy Metal Ions by Poly (Amidoamine) Dendrimer-Functionalized Nanomaterials: A Review. Nanomaterials 2022, 12: 1831.

22. Xiaojing Zheng, Tingfeng Tang, Li Li, Liwen Xu*, Shaohua Huang*, Yufen Zhao. Application of aromatic amide‐derived atropisomers as chiral solvating agents for discrimination of optically active mandelic acid derivatives in 1H nuclear magnetic resonance spectroscopy. Magnetic Resonance in Chemistry 2022, 60: 86-92.

23. Kui Yan, Zhengwu Bai*, Shaohua Huang*. NMR signal separation of ionic liquids by poly (sodium-p-styrenesulfonate)-assisted chromatographic NMR spectroscopy. Magnetic Resonance Letters 2021, 1: 153-159.

24. Dandan Guo, Tingfeng Tang, Shaohua Huang*, Yan Zhu. Methoxy terminated poly dimethylsiloxane bonded stationary phase for reversed-phase liquid chromatography. Journal of Chromatography A 2021, 1652: 462348.

25. Dandan Guo, Shuxin Yu, Nadeem Muhammad, Shaohua Huang*, Yan Zhu*. Poly amidoamine functionalized poly (styrene-divinylbenzene-glycidylmethacrylate) composites for the rapid enrichment and determination of N-phosphoryl peptides. Microchemical Journal 2021, 166: 106213.

26. Xuming Sha, Shaodong Chen, Xiaojing Zheng, Xin Ye, Hailu Zhang*, Shaohua Huang*. Determination of tautomeric preference of fenobam in solution by high‐resolution NMR spectroscopy. Magnetic Resonance in Chemistry 2021, 59: 641-647.

27. Biling Huang, Zhixing Zhao, Yufen Zhao*, Shaohua Huang*. Protein arginine phosphorylation in organisms. International journal of biological macromolecules 2021, 171: 414-422.

28. Tingfeng Tang, Dandan Guo, Shaohua Huang*. Preparation and chromatographic evaluation of the hydrophilic interaction chromatography stationary phase based on nucleosides or nucleotides. Analytical Methods 2021, 13: 419-425.

29. Biling Huang, Zhixing Zhao, Chenyang Huang, Mingxiao Zhao, Yumeng Zhang, Yan Liu, Xinli Liao, Shaohua Huang*, Yufen Zhao*. Role of metal cations and oxyanions in the regulation of protein arginine phosphatase activity of YwlE from Bacillus subtilis. Biochimica et Biophysica Acta (BBA)-General Subjects 2020, 1864: 129698.

30. Dandan Guo, Chenxi Yang, Ruchen Qiu, Shaohua Huang*. A novel imidazolium bonding stationary phase derived from N-(3-aminopropyl)-imidazole for hydrophilic interaction liquid chromatography. Journal of Chromatography A 2020, 1625: 461331.

31. Fei Wang, Chunxi Wang, Yaping Liu, Wenxian Lan, Renxiao Wang, Shaohua Huang, Chunyang Cao*. NMR Studies on the Interaction between Oncogene RET G‐Quadruplex and Berberine. Chinese Journal of Chemistry 2020, 38: 1656-1662.

32. Fei Wang, Chunxi Wang, Yaping Liu, Wenxian Lan, Hao Han, Renxiao Wang, Shaohua Huang, Chunyang Cao*. Colchicine selective interaction with oncogene RET G-quadruplex revealed by NMR. Chemical Communications 2020, 56: 2099-2102.19. Xun Cao, Yutong Shi, Xiaodan Wu, Kuiwu Wang, Shaohua Huang, Hongxiang Sun, Jeroen S Dickschat, Bin Wu*. Talaromyolides A–D and Talaromytin: Polycyclic Meroterpenoids from the Fungus Talaromyces sp. CX11. Organic letters 2019, 21: 6539-6542.

33. Ping Jiang, Liang Chen, Hezhu Shao, Shaohua Huang, Qiushi Wang, Yuebin Su, Xiaoshuang Yan, Xinmiao Liang, Jiujun Zhang, Jiwen Feng*, Zhaoping Liu*. Methylsulfonylmethane-based deep eutectic solvent as a new type of green electrolyte for a high-energy-density aqueous lithium-ion battery. ACS Energy Letters 2019, 4: 1419-1426.

34. Huang, S. H. *; Gao, J.; Wu, R.; Li, S. Y.; Bai, Z. W. * Polydimethylsiloxane: A General Matrix for High-Performance Chromatographic NMR Spectroscopy. Angew. Chem.-Int. Edit. 2014, 53, 11592.

35. Wang, L. M.; Yang, Y.; Yang, H. Y.; Qiu, R. C.*; Huang, S. H.* Direct analysis of succinic acid fermentation broth by 1H diffusion-ordered NMR spectroscopy and quantitative 1H NMR technique. ACS Sustainable Chem. Eng. 2017, 5:2824.

36. Wang, T.; Yang, H. Y.; Qiu, R. C.*; Huang, S. H.* Synthesis of novel chiral imidazolium stationary phases and their enantioseparation evaluation by high-performance liquid chromatography. Anal. Chim. Acta 2016, 944: 70.

37. Tang, S.; Liu, J. D.; Chen, W.; Huang, S. H.*; Zhang, J.; Bai, Z. W.* Performance comparison of chiral separation materials derived from N-cyclohexylcarbonyl and N-hexanoyl chitosans. J. Chromatogr. A 2018, 1532: 112.

38. Yan, K.; Yang, H. Y.; Huang, S. H.*; Bai, Z. W.* A sulfonated chitooligosaccharide modified silica material for hydrophilic interaction liquid chromatography and its chromatographic evaluation. Anal. Methods 2018, 10: 1258.

39. Feng, Z. #; Huang, S. H. #; Chen, W.; Bai, Z. W.* Selective and Full Derivatization of Amino Group in Chitosan with Alkyl Chloroformate of Low Stereo-Hindrance. Macromol. Res. 2016, 24: 650.

40. Yang, Y.; Wu, R.; Huang, S. H.*; Bai, Z. W. Silica sol assisted chromatographic NMR spectroscopy for resolution of trans- and cis-isomers. J. Magn. Reson. 2016, 265, 210.

41. Huang, S. H. *; Wu, R.; Bai, Z. W. *; Yang, Y.; Li, S. Y.; Dou, X. W. Evaluation of the separation performance of polyvinylpyrrolidone as a virtual stationary phase for chromatographic NMR. Magn. Reson. Chem. 2014, 52, 486.

42. Luo, Y. B.; Wang, X. C.; Chen, W.; Huang, S. H. *; Bai, Z. W. * Preparation and Chiral Recognition of Chiral Stationary Phases Derived from Benzoylated Chitosan. Acta Polym. Sin. 2014, 1103.

43. Chen, W.; Duan, R.; Fan, Q. C.; Bai, Z. W. *; Huang, S. H. * Preparation and enantioseparation property of chiral stationary phases based on cellulose tris(3,5-dimethylbenzoate) - A new way to prepare polysaccharide-coating type chiral stationary phases. Chin. J. Polym. Sci. 2014, 32, 458.

44. Huang, S. H.; Bai, Z. W.; Feng, J. W. * Chiral self-discrimination of the enantiomers of alpha-phenylethylamine derivatives in proton NMR. Magn. Reson. Chem. 2009, 47, 423.

45. Huang, S. H.; Zhang, J. Y.; Li, S. R.; Yin, C. Q.; Pan, Z. Q.; Bai, Z. W. * Preparation and enantioseparation of polymer-type chiral stationary phases derived from (1S,2R)-(+)-2-amino-1,2-diphenylethanol. J. Liq. Chromatogr. Relat. Technol. 2008, 31, 2554.

46. Huang, S. H.; Bai, Z. W. *; Yin, C. Q.; Li, S. R.; Pan, Z. Q. Synthesis of polymer-type chiral stationary phases and their enantioseparation evaluation by high-performance liquid chromatography. Chirality 2007, 19, 129.

47. Huang, S. H.; Li, S. R.; Bai, Z. W. *; Pan, Z. Q.; Yin, C. Q. Dendrimer-like chiral stationary phases derived from (1R, 2R)-(+)-1, 2-diphenylethylenediamine and 1,3,5-benzenetricarbonyl trichloride. Chromatographia 2006, 64, 641.

48. Huang, S. H.; Bai, Z. W. *; Yin, C. Q.; Li, S. R. Covalently bonding chiral polyurethane on aminated silica gel: A new strategy topreparie chiral stationary phase for high performance liquid chromatography. Chin. J. Polym. Sci. 2006, 24, 107.

49. Tang, S.; Mei, X. M.; Chen, W.; Huang, S. H.; Bai, Z. W. A high-performance chiral selector derived from chitosan (p-methylbenzylurea) for efficient enantiomer separation. Talanta 2018, 185, 42.

50. Qiu, G. S.; Yan, K.; Zhang, S.; Chen, W.; Huang, S. H.; Bai, Z. W.* Different molecular weight chitosan derivatives employed for enantiomeric separation. Anal. Methods 2017, 9: 6560.

51. Bai, Z. W.; Yang, F.; Fu, K. Q.; Wang, X. C.; Liu, J. D.; Chen, W.; Huang, S. H.; Tang, S.* Evaluation and comparison of N-cycloalkylformylated chitosan bis(arylcarbamate)s as chiral selectors for enantioseparation. New J. Chem. 2017, 41: 10561.

52. Liang, S.; Huang, S. H.; Chen, W.; Bai, Z. W.* High-performance chiral stationary phases based on chitosan derivatives with a branched-chain alkyl urea. Anal. Chim. Acta 2017, 985: 183.

53. Feng, Z. W.; Qiu, G. S.; Mei, X. M.; Liang, S.; Yang, F.; Huang, S. H.; Chen, W.; Bai, Z. W.* Structural dependence on the property of chiral stationary phases derived from chitosan bis(arylcarbamate)-(amide)s. Carbohyd. Polym. 2017, 168: 301.

54. Wang, J.; Xi, J. B.; Chen, W.; Huang, S. H.; Bai, Z. W. High performance chiral separation materials based on chitosan bis(3,5-dimethylphenylcarbamate)-(alkyl urea)s. Carbohyd. Polym. 2017, 156: 481.

55. Wang J.; Huang S. H.; Chen W.; Bai Z. W. * Eluent Tolerance and Enantioseparation Recovery of Chiral Packing Materials Based on Chitosan Bis(Phenylcarbamate)-(n-Octyl Urea)s for High Performance Liquid Chromatography. Molecules 2016, 21: 1528.

56. Tang S.; Bin Q.; Chen W.; Bai Z. W.*; Huang S. H. Chiral stationary phases based on chitosan bis(methylphenylcarbamate)-(isobutyrylamide) for high-performance liquid chromatography. J. Chromatogr. A 2016, 1440: 112.

57. Tang S.; Liu J.; Bin Q.; Fu K.; Wang X.; Luo Y,; Huang S. H.; Bai Z. W.* N-Acylated chitosan bis(arylcarbamate)s: A class of promising chiralseparation materials with powerful enantioseparation capability andhigh eluents tolerability. J. Chromatogr. A 2016, 1476: 53.

58. Zhang, W.; Cao, S. N.; Qiu, L.; Qi, F. X.; Li, Z.; Yang, Y.; Huang, S. H.; Bai, F. L.; Liu, C. N.; Wan, X. B.; Li, S. Y.* Functional Characterization of MpaG ', the O-Methyltransferase Involved in the Biosynthesis of Mycophenolic Acid. Chembiochem 2015, 16, 565.

59. Li, S. Y.; Jia, M. J.; Gao, J.; Wu, P.; Yang, M. L.; Huang, S. H.; Dou, X. W.; Yang, Y.; Zhang, W. X.* Infrared Studies of the Promoting Role of Water on the Reactivity of Pt/FeOx Catalyst in Low-Temperature Oxidation of Carbon Monoxide. J. Phys. Chem. C 2015, 119, 2483.

60. Zhang, W.; Liu, Y.; Yan, J. Y.; Cao, S. N.; Bai, F. L.; Yang, Y.; Huang, S. H.; Yao, L. S.; Anzai, Y.; Kato, F.; Podust, L. M.; Sherman, D. H.; Li, S. Y.* New Reactions and Products Resulting from Alternative Interactions between the P450 Enzyme and Redox Partners. J. Am. Chem. Soc. 2014, 136, 3640.

61. Song, B. *; Sun, Q.; Li, H. K.; Ge, B. S.; Pan, J. S.; Wee, A. T. S.; Zhang, Y.; Huang, S. H.; Zhou, R. H.; Gao, X. Y.; Huang, F. *; Fang, H. P. Irreversible Denaturation of Proteins through Aluminum-Induced Formation of Backbone Ring Structures. Angew. Chem.-Int. Edit. 2014, 53, 6357.

62. Ru, G. Y.; Wang, N.; Huang, S. H.; Feng, J. W.* H-1 HRMAS NMR Study on Phase Transition of Poly(N-isopropylacrylamide) Gels with and without Grafted Comb-Type Chains. Macromolecules 2009, 42, 2074.

63. Yin, C. Q.; He, B. J.; Huang, S. H.; Zhang, J. Y.; Bai, Z. W.*; Li, Z. Y. Synthesis of dendritic stationary phases with surface-bonded L-phenylalanine derivate as chiral selector and their evaluation in HPLC resolution of racemic compounds. Chirality 2008, 20, 846.


 发明专利 Patents:

1. 吴西俭,黄少华,佟馨,苏子杰,一种快速检测混合体系中胺类的伪二维19F核磁共振波谱法,中国发明专利, 2024,CN202410299424.6

2. 郭丹丹,  周晓倩,  应见喜,  黄少华,  赵玉芬,  一种多肽改性纤维素的绿色制备方法,中国发明专利, 2023,CN202211382246.0

3. 肖琪,黄少华,郭丹丹,一种二苯氧磷‑6‑氧化物反相色谱固定相及制备方法及应用,中国发明专利,2023,CN202211352740.2

4. 黄碧玲,徐丽华,黄少华,一种巯基化合物的分析方法,中国发明专利,2022,CN202210561533.1

5. 余玲燕,陶卫东,沙旭明,黄少华,一种含有二氢杨梅素的双光子材料及其制备方法和应用,中国发明专利,2022,CN202210323183.5

6. 黄碧玲,黄少华,一种快速识别葡萄糖手性的试剂及其制备方法和应用,中国发明专利,2021,CN202111637551.5

7. 沙旭明,黄少华,韩博闻,孙杉杉,一种对映体纯二氢杨梅素制备方法,中国发明专利,2021,CN202111356732.0

8. 黄少华,孙杉杉,沙旭明,郭丹丹,一种二氢杨梅素的消旋化保护方法,中国发明专利,2021,CN202111299152.2

9. 韩博闻,赵玉芬,黄少华,郭丹丹,孙杉杉,一种二氢杨梅素的单一构型提取方法,中国发明专利,2021,ZL202110289675.2

10. 黄少华,韩博闻,郭丹丹,一种二氢杨梅素的对映体手性识别方法,中国发明专利,2021,ZL 202110275773.0

11. 黄碧玲,黄少华,赵玉芬,一种手性衍生化试剂及其制备方法和应用,中国发明专利,2021,ZL 202110238438.3

12. 黄碧玲,黄少华,赵玉芬,一种鉴别氨基酸的方法,中国发明专利,2021,ZL 202110253181.9

13. 俞书馨,郭丹丹,黄少华,一种增强金属有机框架材料荧光性能的方法,中国发明专利,2021,ZL 202110145659.6

14. 黄少华,沙旭明,郭丹丹,韩博闻,一种对映体纯氯喹及磷酸氯喹的制备方法,中国发明专利,2020,CN202011112856.X

15. 郭丹丹,黄少华,俞书馨,一种聚酰胺-胺树状大分子接枝型吸附材料用于溶液中磷酰化药物快速富集的方法及应用,中国发明专利,2020,CN202011105041.9

16. 唐廷峰,黄少华,郭丹丹,核苷类亲水作用色谱固定相及制备方法及应用,中国发明专利,2020,CN202010330013.

17. 黄少华,严 葵,杨海燕,苯甲醛-2-磺酸钠衍生化壳聚糖亲水色谱固定相及制备和应用,中国发明专利,2017,ZL 201711018365.7

18. 黄少华,朱 萌,一种MT-PDMS键合硅胶反相高效液相色谱固定相及其制备和应用,中国发明专利,2017,CN 201711212974.6

19. 黄少华,王 涛,杨海燕,一种咪唑类离子液体型手性固定相和制备方法及应用,中国发明专利,2016,ZL 201610411417.6

20. 黄少华,杨晨曦,杨海燕,陈骁, 一种氨基咪唑类离子液体型亲水作用色谱固定相的制备方法和应用,中国发明专利,2016,ZL 2016 11096168.2

21. 黄少华,杨晨曦,杨海燕,高峻, 一种亲水作用色谱/离子交换色谱混合固定相的制备方法和应用,中国发明专利,2016,ZL 2016 11096715.7

22. 黄少华,高 峻,李素英,豆孝伟,杨 盈,一种用于核磁共振波谱的添加剂及利用其对混合物的分析方法,中国发明专利,2014,CN201410499240.0


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