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任永申 中药学博士 研究员 Email:renyongshen(AT)nbu.edu.cn
研究领域(Research area):
中药学及相关交叉学科
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个人简介(Personal Brief Introduction):
主要研究领域为中药学,涉及中药基础理论研究、中药药效物质辨识与作用机制研究、中药质量与品质评价研究、中药动物药研究、中药鲜药研究、中药外泌体研究、航天中药研究、中药大品种二次开发研究、中药制剂与新药开发研究、中药大健康产品开发研究等。
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教育与科研经历(Education Experience):
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2025.08-至今 | 宁波大学新药技术研究院,研究员,硕博导
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2023.07-2025.07 | 海南大学药学院,研究员、硕博导
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2015.03-2017.02 | 耶鲁大学医学院,公派访学、博后 |
2011.06-2023.06 | 中南民族大学药学院,讲师、副教授、硕导 |
2001.09-2011.06 | 成都中医药大学药学院中药学专业本科、硕士、博士 |
科研项目(Funding and Projects):
国家自然科学基金面上项目,基于功效多向性与谱效灰色关联分析的中药药效物质辨识与质量控制研究,主持; 国家自然科学基金青年项目,基于多模态生物影像技术检测炮制对黄连升降浮沉作用趋向的影响,主持; 国家重大新药创制计划子课题,基于民族医药理论的创新民族药物有效性评价关键技术研究,主持。
奖励(Awards):
湖北省科技进步奖二等奖,基于功效导向的中药药效物质辨识关键技术及应用,第一完成人,2021年; 土家药的化学成分研究及应用,中国民族医药学会科学技术奖二等奖,第五完成人,2020年; 湖北省高等学校教学成果奖特等奖,产业需求导向的民族高校药学创新人才培养体系构建与实践,第十完成人,2022年。 |
代表性论文(Research Paper Published):
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[1] Huiling Tian, Long Cheng, Yunhui Liang, Hongyuan Lei, Miaomiao Qin, Xinyun Li, Yongshen Ren(*). MicroRNA therapeutic delivery strategies: A review. Journal of Drug Delivery Science and Technology. 2024, 93: 105430
[2] CHENG Long, TIAN Hui-lin, LEI Hong-yuan, WANG Ying-zhou, JIAO Ma-jing, LIANG Yun-hui, WU Zhi-zheng, DENG Xu-kun, REN Yong-shen (*). Bear Bile Powder Ameliorates LPS-Induced Acute Lung Injury by Inhibiting CD14 Pathway and Improving Intestinal Flora: Exploration of Fei (Lung)-Large Intestine Interaction. Chinese Journal of Integrative Medicine. 2023: 3556-9
[3] Liu, P. (#), Ye, L. (#), Ren, Y. (#), Zhao, G., Zhang, Y., Lu, S., Li, Q., Wu, C., Bai, L., Zhang, Z., Zhao, Z., Shi, Z., Yin, S., Liao, M., Lan, Z., Feng, J., & Chen, L.. Chemotherapy-induced phlebitis via the GBP5/NLRP3 inflammasome axis and the therapeutic effect of aescin. British Journal of Pharmacology, 2023, 180(8), 1132–1147.
[4] Jiao Ai, Yong-Shen Ren(*),Long Cheng, Xin-Qiao Liu, Yan-Qiu Li, Ma-Jing Jiao, Ying-Zhou Wang, Xin Deng, Lin-Lin Chen. Identification of key genes and active anti-inflammatory ingredients in Panax medicinal plants by climate-regulated callus culture combined with gene-component-efficacy gray correlation analysis. Acupunct Herb Med. 2022; 2(4): 261–273. doi: 10.1097/HM9.0000000000000049
[5] Xin Deng(1), Hong-Yuan Lei(1), Yong-Shen Ren(*), Jiao Ai, Yan-Qiu Li, Shuai Liang, Lin-Lin Chen, Mao-Chuan Liao. A novel strategy for active compound efficacy status identification in multi-tropism Chinese herbal medicine (Scutellaria baicalensis Georgi) based on multi-indexes spectrum-effect gray correlation analysis. Journal of Ethnopharmacology. 2022, 300, 115677
[6] Majing Jiao(1), Xinqiao Liu(1), Yongshen Ren(*), Yingzhou Wang, Long Cheng, Yunhui Liang,Yanqiu Li, Tianpei Zhang, Wen Wang and Zhinan Mei. Comparison of herbal medicines used for women’s menstruation diseases in different areas of the world. Frontiers in Pharmacology. 2021: 751207
[7] Zheng Yao, Lei Lei, Liang Shuai, Ai Jiao, Deng Xin, Li Yan-qiu, Zhang Tian-pei, Pu Shi-biao, and Ren Yong-shen(*).Protective Effect of Fresh/Dry Dandelion Extracts on APAP-Overdose-Induced Acute Liver Injury. Chinese Journal of Integrative Medicine. 2021, 11655
[8] Yongshen Ren(*), Shuai Liang, Yao Zheng, Xin Deng, Lei Lei, Jiao Ai, Yanqiu Li. Tianpei Zhang, Linlin Chen, Zhinan Mei, Yung-Chi Cheng, Caijing He. Investigation on the function tropism of Tiaoqin and Kuqin (different specification of Scutellaria baicalensis) by comparing their curative effect on different febrile disease model. Journal of Ethnopharmacology. 2021, 268, 113596
[9] Yongshen Ren(*), Jiao Ai, Xinqiao Liu, Shuai Liang, Yao Zheng, Xin Deng, Yan Li, Jing Wang, Xukun Deng, Linlin Chen(*). Anticoagulant active ingredients identification of total saponin extraction of different Panax medicinal plants based on grey relational analysis combined with UPLC-MS and molecular docking. Journal of Ethnopharmacology. 2020, 251: 112955
[10] Yongshen Ren(1,*) , Yao Zheng(1), Huan Duan, Lei Lei, Xin Deng, Xinqiao Liu, Xukun Deng (*). Dandelion polyphenols protect against acetaminophen induced hepatotoxicity in mice via activating the Nrf-2/HO-1 and inhibiting the JNK signaling pathway. Chinese Journal of Natural Medicines. 2020, 18(2): 103–113
[11] Liang Shuai(1), Deng Xin (1), Lei Lei, Zheng Yao, Ai Jiao, Linlin Chen, Zhinan Mei, Yung-Chi Cheng(*) and Yongshen Ren(*). The comparative study of the therapeutic Effects and mechanisms of Baicalin, Baicalein and their Combinations on ulcerative colitis rat Fronters in Pharmacology Ethnopharmacology. 2019, 01466
[12] Ren Yongshen(*,1), Lei Lei(1), Deng Xin, Zheng Yao, Li Yan, Li Jun, Mei Zhinan (*). Novel application of neural network modelling for multicomponent herbal medicine optimization. Scientific Reports. 2019.
[13] Feifei Zhang(1), Jie Ba (1) , Lei Lei, Yao Zheng, Xin Deng, Weijun Li, Peng Liu, Yongshen Ren(*). Investigation on the Optimum Preparation of Peach Gum Polysaccharides and Its Therapeutic Effects and Mechanisms on Acute Pyelonephritis in Vivo and Vitro. Evidence-based Complementary and Alternative Medicine. 2019.
[14] Haida Teng(1), Yongshen Ren(1), Ziyu Ma, Xue Tan, Jing Xu, Yu Chen, Guangzhong Yang(*). Homoadamantane polycyclic polyprenylated acylphloroglucinols from the fruits of Garcinia multiflora. Fitoterapia. 2019, 137: 104245
[15] Jie Yang, Shihao Deng, Mi Huang, Xinhua Ma, Ping Song, Jingwen Du, Yun Huang, Yanzhang Wen, Yongshen Ren(*), Xinzhou Yang(*). Inhibitory effect of kurarinone on growth of human non-small cell lung cancer: an experimental study both in vitro and in vivo studies. Frontiers in Pharmacology Ethnopharmacology. 2018. DOI: 10.3389/fphar.2018.00252
[16] Yongshen Ren, Ziliang Yuan, Kangle Lv, Jie Sun, Zehui Zhang(*) , Quan Chi. Selective and metal-free oxidation of biomass derived 5-hydroxymethylfurfural to 2,5-diformylfuran over nitrogen-doped carbon materials. Green Chemistry. 2018. 20: 4946
[17] Wing Lam, Ren Yongshen, Fulan Guan, Zaoli Jiang, William Cheng, Shwuhuey Liu, Yung-Chi Cheng(*). Mechanism Based Quality Control (MBQC) for quality control of herbal products: a case study YIV-906 (PHY906). Fronters in Pharmacology Ethnopharmacology. 2018.01324
[18] Yongshen Ren,Ping Zhang,Dan Yan,Yan Yan,Longhu Chen,Lingling Qiu,Zhinan Mei,Xiaohe Xiao(*),Application ofmicrocalorimetryof Escherichia coli growth and discriminant analysis to th equality assessment of a Chinese herbal injection(Yinzhihuang). Acta Pharmaceutica Sinica B. 2012,2(2): 278-285
[19] Manrong Tan(#),Yongshen Ren(#),Yan Dan(*),Mengxiang Hong,Longhu Chen,Lingling Qiu,Yan Yan,Jianyu Li,Xiaohe Xiao(*),Detection of microorganisms in different growth states based on microcalorimetry,J Therm Anal Calorim,2012, 109: 1069-1075
[20] Yongshen Ren(#),Ping Zhang(#),Yan Dan(*),JB Wang,Xiaoxi Du,XiaoHe Xiao(*). A strategy for the detection of quality fluctuation of a Chinese herbal injection based on chemical fingerprinting combined with biological fingerprinting.,J Pharm Biomed Anal., 2011, 56(2): 436-442