研究队伍

副研究员

 Email：lilong(AT)nbu.edu.cn

研究领域：

代谢性疾病

肝脏疾病

炎症

脂代谢

药理学

个人简介：

主要研究领域为药理学及化学生物学研究。近期研究重点主要包括非酒精性脂肪肝、急性肝损伤等肝脏疾病的发病机制研究及药物筛选；大枣等食药同源物质的抗辐射等功效研究及产品开发。目前为中国药理学会心血管专业委员会第三届青年委员，作为副主编参与编写科普书籍1部（180千字），受邀担任《Molecular Biomedicine》、《Cell Death Discov》、《Apoptosis》、《BMC Genomics》、《Food & Function》等期刊审稿人。

教育与科研经历：

2005.09-2009.07

山东大学，生物技术，学士

2009.09-2015.12

厦门大学，化学生物学，博士

2018.08-至今

宁波大学新药技术研究院，副研究员

 主持项目：

（1）浙江省自然科学基金, LQ21H030002

（2）宁波市自然科学基金, 2023J071

（3）宁波市自然科学基金, 2019A610209

（4）企业横向项目

（5）国家重点实验室开放课题

代表性论文：

[1] M. Tao#; J. Shi#; Y. Zhang; Y. Zheng; Y. Zhao; H. Ma*; L. Li*. Berbamine attenuates acetaminophen-induced liver injury by engaging GCLC and enhancing ferroptosis-regulatory antioxidant pathways. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2026, 1872(4): 168154.

[2] Y. Zheng; H. Ying; J. Shi; H. Yang; L. Yang; N. Wang; Y. Zhao; H. Ma*; L. Li*. Fucoxanthin Protects Against Acute Liver Injury by Inhibiting NOD-Like Receptor Protein 3 Inflammasome-Mediated Pyroptosis Through the Mitogen-Activated Protein Kinases and Nuclear Factor-Kappa B Pathway. Phytotherapy Research, 2026, 40(7): 4471-4484.

[3] T. Gao; W. Zhong; M. Tao; Y. Guo; K. Yang; Y. He; G. Hu;L. Li*; X. Kong; F. Li*; Y. Zhao. Hypomagnetic Field Enhances U2OS Cell Proliferation and Migration by Promoting β-Catenin Phosphorylation and Upregulating FN1 and LOX Expression. Cells, 2026, 15(8): 727.

[4] L. Wang; H. Yang; X. Zhou; Y. Zhao; L. Li*; N. Wang*. Radioprotective Efficacy of Jujube Aqueous Extract and Arbutin: Synergistic Antioxidant and Anti-Apoptotic Mechanisms in Radiation Injury. Food Science Nutrition, 2025, 13(10).

[5] Y. Shi#; C. Wu#; J. Shi; T. Gao; H. Ma*; L. Li*; Y. Zhao. Protein phosphorylation and kinases: Potential therapeutic targets in necroptosis. European Journal of Pharmacology, 2024, 970.

[6] Y. Zheng; H. Ying; J. Shi; L. Li*; Y. Zhao. Alanyl-Glutamine Dipeptide Attenuates Non-Alcoholic Fatty Liver Disease Induced by a High-Fat Diet in Mice by Improving Gut Microbiota Dysbiosis. Nutrients, 2023, 15(18): 3988.

[7] J. Hu; H. Ying; Y. Zheng; H. Ma; L. Li*; Y. Zhao. Alanyl-Glutamine Protects against Lipopolysaccharide-Induced Liver Injury in Mice via Alleviating Oxidative Stress, Inhibiting Inflammation, and Regulating Autophagy. Antioxidants, 2022, 11(6): 1070.

[8] H. Ying; L. Li*; Y. Zhao; F. Ni*. Ivermectin Attenuates CCl4-Induced Liver Fibrosis in Mice by Suppressing Hepatic Stellate Cell Activation. International Journal of Molecular Sciences, 2022, 23(24): 16043.

[9] Z. Zhu; J. Shi; L. Li*; J. Wang*; Y. Zhao; H. Ma*. Therapy Targets SARS-CoV-2 Infection-Induced Cell Death. Frontiers in Immunology, 2022, 13: 870216.

[10] J. Hu; Y. Zheng; H. Ying; H. Ma; L. Li*; Y. Zhao. Alanyl-Glutamine Protects Mice against Methionine- and Choline-Deficient-Diet-Induced Steatohepatitis and Fibrosis by Modulating Oxidative Stress and Inflammation. Nutrients, 2022, 14(18): 3796.

[11] J. Hu; H. Ying; J. Yao; L. Yang; W. Jin; H. Ma; L. Li*; Y. Zhao. Micronized Palmitoylethanolamide Ameliorates Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Steatohepatitis via Inhibiting Inflammation and Restoring Autophagy. Frontiers in Pharmacology, 2021, 12: 744483.

[12] J. Hu; Z. Zhu; H. Ying; J. Yao; H. Ma; L. Li*; Y. Zhao*. Oleoylethanolamide Protects Against Acute Liver Injury by Regulating Nrf-2/HO-1 and NLRP3 Pathways in Mice. Frontiers in Pharmacology, 2021, 11: 605065.

[13] L. Li#; C. Huang; H#. Yin; X. Zhang; D. Wang; C. Ma; J. Li; Y. Zhao*; X. Li*. Interleukin-6 mediated exercise-induced alleviation of adiposity and hepatic steatosis in mice. BMJ Open Diabetes Res Care, 2021, 9(1): 1-11.

[14] W. Jin; L. Yang; Z. Yi; H. Fang; W. Chen; Z. Hong; Y. Zhang*; G. Zhang*; L. Li*. Anti-Inflammatory Effects of Fucoxanthinol in LPS-Induced RAW264.7 Cells through the NAAA-PEA Pathway. Marine Drugs, 2020, 18(4): 222.

[15] L. Li#; H. Yin#; Y. Zhao; X. Zhang; C. Duan; J. Liu; C. Huang; S. Liu; S. Yang; X. Li*. Protective role of puerarin on LPS/D-Gal induced acute liver injury via restoring autophagy. American Journal of Translational Research, 2018, 10(30): 957-965.

[16] L. Li#; C. Duan#; Y. Zhao; X. Zhang; H. Yin; T. Wang; C. Huang; S. Liu; S. Yang*; X. Li*. Preventive effects of Interleukin-6 in Lipopolysaccharide/D-Galactosamine induced acute liver injury via regulating inflammatory response in hepatic macrophages. International Immunopharmacology, 2017, 51: 99-106.

[17] L. Li; L. Li; L. Chen; X. Lin; Y. Xu; J. Ren; J. Fu; Y. Qiu*. Effect of oleoylethanolamide on diet-induced nonalcoholic fatty liver in rats. Journal of Pharmacological Sciences, 2015, 127(3): 244-250.

[18] L. Yang#; L. Li#; L. Chen; Y. Li; H. Chen; Y. Li; G. Ji; D. Lin; Z. Liu*; Y. Qiu*. Potential analgesic effects of a novel N-acylethanolamine acid amidase inhibitor F96 through PPAR-alpha. Scientific Reports, 2015, 5: 13565.

 授权发明专利：