研究队伍

副研究员

Email：wuju(AT)nbu.edu.cn

研究方向：

有机电化学合成

个人简介：

吴巨，副研究员，硕士生导师，宁波大学新药研究院“学术骨干”；2020年获法国Université Paris-Sud（现Université Paris-Saclay）有机化学博士学位；主要从事有机电化学去芳构化吲哚研究及磷自由基环化反应。截至目前，以第一作者或通讯作者发表J. Am. Chem. Soc.、Org. Lett. 、Chem. Commun.、Org. Chem. Front., J. Org. Chem., Adv. Synth. Catal., 等国际高水平原创学术论文20余篇论文。承担一项国家青年科学基金和一项浙江省青年探索项目。并担任《Organic Letters》, 《JACS Au》, 《JACS Au》《Chemical Communications》, 《Chinese Journal of Chemistry》等杂志审稿人。

 荣誉和奖励:

2020.10                                                                                以“学术骨干”加入宁波大学新药研究院

2016.10-2020.10                                                     国家留学基金委员会建设中国高水平大学公派研究生项目

 科研项目：

1、国家自然科学青年基金，22201150，30万，主持。

2、浙江省自然科学基金探索青年项目，LQ22B020009，10万，主持。

3、宁波市自然科学基金一般项目，2024J283，6万，主持

国际会议及学术访问：

WU Ju, Electrochemical dearomative 2,3-difunctionalization of indoles.  17th Meeting of Organic Chemistry, Paris, France, 19th Apirl, 2019. (Oral presentation)

WU Ju, Electrochemical dearomative 2,3-difunctionalization of indoles.  Electrifying Organic Synthesis, Beilstein Organic Chemistry Symposium 2019. Mainz, Germany, 9-11^th Apirl, 2019. (Poster)

WU Ju, Symposium of Organometallic Chemistry. Chimie ParisTech, Paris, 12^th September, 2018.

WU Ju, 24th edition of the Young Researcher Follow's Meeting of the French Medicinal Chemistry Society. Paris, 7^th December, 2017.

代表性论文：

1. Zhu, R.; Guo, X.; Shen, Y.; Xu, F.; Zhao, Y.; Wu, J.* Electrochemical Dearomative Reduction of Indole Derivatives Mediated by Ph₃P(O). Org. Lett. 2026, 28, 2666.

2. Wang, J.; Chen, S.; Sun, D.; Shen, Y.; Zhao, Y.; Wu, J.* Alternating Current Polarity for Electrochemical De Novo Synthesis of 3, 3'-Bisoxindoles. Chem. Commun. 2026, 62, 5312.

3. Zhu, R.; Xie, T.; Shen, Y.; Zhao, Y. Wu, J.* Tf₂O Mediated Phospha-Michael Addition to Unactivated α, β-Unsaturated Amides. Org. Lett. 2025, 27, 13822-13826.

4. Zhang, Z.; Shen, Y.; Zhao, Y.; Wu, J.* Electrochemical phosphorylation of α,β-unsaturated carboxylic acids via decarboxylative cross-coupling reaction. Chem. Commun., 2025, 61, 12034-12037.

5. Wang, J.; Huang, Y.; Shen, Y.; Li, F.; Zhao, Y.; Wu, J.* Electrochemical synthesis of phosphorylated Glycine-containing oligopeptides. Org. Chem. Front., 2025, 12, 5902-5907.

6. Wang, J.; Zhu, R.; Zhao, Y.; Wu, J.* Electrochemical Dearomatization of Indoles: Access to Diversified Functionalized Spirocyclic Indolines. Topics in Heterocyclic Chemistry; “Construction and Functionalization of Heterocycles by Electrochemistry” 2024, 61, 91-112. (Invited by Prof. Eric Nacsa from Pennsylvania State University).

7. Zhou, X.; Wang, J.; Ma, D.; Shen, Y.; Zhao, Y. Wu, J.* Electrochemical Synthesis of Phosphorylated Azaspiro[4.5]di/trienones through Dearomative Spirocyclization. Chem. Commun. 2024, 60, 7351-7354.

8. Wu, J.* Zhao, Y. Recent Advances in Electrochemical Synthesis of Diversified Functionalized Spiro [N. 5]Enone Derivatives. TARGETS IN HETEROCYCLIC SYSTEMS - Chemistry and Properties (THS) Volumes 27 (2023) (Invited by Prof. Orazio Antonio Attanasi, the editor from the Italian Chemical Society).

9. Wang, J.; Zhang, Z.; Shen, Y.; Zhao, Y. Wu, J.* Electrochemical Synthesis of Phosphorylated Indoles and Trp-Containing Oligopeptides. Org. Lett. 2024, 26, 4700-4704.

10. Zhu, R.; Ma, D.; Zhao, Y. Wu, J.* Cp₂Fe-Mediated Electrochemical Synthesis of Functionalized Compounds: Recent Advances. Eur. J. Org. Chem. 2024, 12, e202400021. (Invited by the editor of European Journal of Organic Chemistry).

11. Zhou, X.; Wang, J.; Shen, Y.; Ma, D.; Zhao, Y. Wu, J.* Cp2Fe-Mediated Electrochemical Synthesis of Phosphorylated Oxindoles and Indolo[2,1-a]isoquinolin-6(5H)-ones. J. Org. Chem. 2023, 88, 17521-17526.

12. Zhou, X.; Wu, J.*; Zhao, Y. Recent Advances in Electrochemical Synthesis of Diversified Functionalized Oxindole Derivatives, Org. Chem. Front. 2023, 10, 3929-3950.

13. Mo, K.; Zhou, X.; Wang, J.; Wu, J.*; Zhao, Y. Cp₂Fe Mediated Electrochemical Synthesis of Phosphonylated Spirocyclic Indolines via Dearomatization of Indoles, Org. Lett. 2023, 25, 3956-3960.

14. Mo, K.; Zhou, X.; Wu, J.*; Zhao, Y. Manganese-Mediated Electrochemical Dearomatization of Indoles to Access 2-Azido Spirocyclic Indolines, J. Org. Chem. 2022, 87, 16106-16110.

15. Mo, K.; Zhou, X.; Wu, J.*; Zhao, Y. Electrochemical Dearomatization of Indoles: Access to Diversified Fluorine-Containing Spirocyclic Indolines, Org. Lett. 2022, 24, 2788-2792.

16. Mo, K.; Zhou, X.; Wu, J.*; Zhao, Y.* Radical-Induced Denitration of N-(p-nitrophenyl) Propiolamides coupled with Dearomatization: Access to Phosphonylated/trifluoromethylated Azaspiro [4.5]-trienones, Chem. Commun. 2022, 58, 1306-1309.

17. Wu, J.; Guillot, R.; Kouklovsky, C.; Vincent, G. Electrochemical Dearomative Dihydroxylations, Hydroxycyclizations of Indoles, Adv. Synth. Catal. 2020, 362, 1712-1719.

18. Wu, J.; Abou-Hamdan; H., Guillot, R.; Kouklovsky, C.; Vincent, G. Electrochemical Synthesis of 3a-Bromofuranoindolines and 3a-Bromopyrroloindolines Mediated by MgBr₂, Chem. Commun. 2020, 56, 1713-1716.

19. Wu, J.; Ma, D.; Tang G.; Zhao Y.; Copper-Catalyzed Phosphonylation/Trifluoromethylation of N-p-NO2-benzoylacrylamides Coupled with Denitration and Dearomatization, Org. Lett. 2019, 21, 7674-7678.

20. Wu, J.; Dou, Y.; Guillot, R.; Kouklovsky, C.; Vincent, G. Electrochemical Dearomative 2,3-Difunctionalization of Indoles. J. Am. Chem. Soc. 2019, 141, 2832–2837.

21. Wu, J.; Nandi, R. K.; Guillot, R.; Kouklovsky, C.; Vincent, G. Dearomative Diallylation of N-Acylindoles Mediated by FeCl₃. Org. Lett. 2018, 20, 1845–1848.